Abstract：
BACKGROUND: Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder associated with a broad symptom presentation that is still being characterized. We report a rare case of recurrent mycoplasma skin abscesses in a patient with a history of autoimmune disorders and prolonged mycoplasma pneumonia who was diagnosed with CVID.
METHODS: A 34-year-old woman presented with a history of recurrent abscesses previously confirmed positive for Mycoplasma pneumoniae. Her past medical history of recurrent mycoplasma abscesses, prolonged mycoplasma pneumonia, and autoimmune disorders (mixed connective tissue disease and immune thrombocytopenia) raised suspicion of CVID. Workup included negative anti-mycoplasma antibody titers, hypogammaglobulinemia, and negative anti-pneumococcal antibody titers despite prior vaccination, solidifying the diagnosis of CVID. The patient was discharged on antibiotic and intravenous immunoglobulin therapy and now follows allergy and immunology long-term for treatment.
CONCLUSIONS: Her diagnostic history underscores the importance of considering the various criteria of CVID for diagnosis, and her unique presentation of M. pneumoniae skin abscesses highlights the broad sequelae patients with CVID can manifest.
METHODS: A 34-year-old woman presented with a history of recurrent abscesses previously confirmed positive for Mycoplasma pneumoniae. Her past medical history of recurrent mycoplasma abscesses, prolonged mycoplasma pneumonia, and autoimmune disorders (mixed connective tissue disease and immune thrombocytopenia) raised suspicion of CVID. Workup included negative anti-mycoplasma antibody titers, hypogammaglobulinemia, and negative anti-pneumococcal antibody titers despite prior vaccination, solidifying the diagnosis of CVID. The patient was discharged on antibiotic and intravenous immunoglobulin therapy and now follows allergy and immunology long-term for treatment.
CONCLUSIONS: Her diagnostic history underscores the importance of considering the various criteria of CVID for diagnosis, and her unique presentation of M. pneumoniae skin abscesses highlights the broad sequelae patients with CVID can manifest.
摘要：
背景：常见可变免疫缺陷（CVID）是一种与广泛症状表现相关的原发性免疫缺陷疾病，目前仍在表征中。我们报告了一例罕见的支原体皮肤脓肿，该患者有自身免疫性疾病和长期支原体肺炎病史，被诊断为CVID。
方法：一名34岁女性，有反复脓肿病史，先前证实肺炎支原体阳性。她过去的支原体脓肿复发病史，长期支原体肺炎，和自身免疫性疾病（混合性结缔组织病和免疫性血小板减少症）引起了CVID的怀疑。检查包括抗支原体抗体滴度阴性，低球蛋白血症,和阴性的抗肺炎球菌抗体滴度，尽管事先接种疫苗，巩固CVID的诊断。该患者接受抗生素和静脉注射免疫球蛋白治疗后出院，现在长期接受过敏和免疫学治疗。
结论：她的诊断史强调了考虑CVID的各种诊断标准的重要性，她对肺炎支原体皮肤脓肿的独特表现突出了CVID患者的广泛后遗症。
方法：一名34岁女性，有反复脓肿病史，先前证实肺炎支原体阳性。她过去的支原体脓肿复发病史，长期支原体肺炎，和自身免疫性疾病（混合性结缔组织病和免疫性血小板减少症）引起了CVID的怀疑。检查包括抗支原体抗体滴度阴性，低球蛋白血症,和阴性的抗肺炎球菌抗体滴度，尽管事先接种疫苗，巩固CVID的诊断。该患者接受抗生素和静脉注射免疫球蛋白治疗后出院，现在长期接受过敏和免疫学治疗。
结论：她的诊断史强调了考虑CVID的各种诊断标准的重要性，她对肺炎支原体皮肤脓肿的独特表现突出了CVID患者的广泛后遗症。
