PDF(Pubmed)
Abstract：
This case report describes a 22-year-old male patient diagnosed with schizoaffective disorder. A multidrug regimen including olanzapine and lorazepam was initiated for the patient. Sodium valproate was added to the regimen in due course and it was associated with bicytopenia in the form of thrombocytopenia and leukopenia. Valproate was identified as the offending drug and further doses were withheld. Lithium was used as a substitute to valproate and the patient spontaneously recovered without any further complications. This case report highlights the necessity of periodic investigations and frequent logging of blood indices to counter the threat of fatal adverse drug reactions.
摘要：
此病例报告描述了一名22岁的男性患者，被诊断患有分裂情感障碍。为患者启动了包括奥氮平和劳拉西泮在内的多药方案。在适当的时候，丙戊酸钠被添加到方案中，它与血小板减少症和白细胞减少症形式的双环减少症有关。丙戊酸被确定为不良药物，并保留了进一步的剂量。锂被用作丙戊酸盐的替代品，患者自发康复，没有任何其他并发症。此病例报告强调了定期调查和频繁记录血液指标以应对致命药物不良反应威胁的必要性。
