PDF(Pubmed)
Abstract：
Asperger syndrome (AS) is a chronic neurodevelopmental disorder. Although all of the clinically diagnosed cases display normal intelligence and speech functions, barriers in social interaction and communication seriously affect mental health and psychological function. In addition to traditional psychological/behavioral training and symptomatic medication, in-depth studies of intestinal microbiota and mental health have indicated that probiotics (e.g., Lactobacillus rhamnosus) can effectively reduce the occurrence of AS. Fecal microbiota transplantation (FMT) is a type of biological therapy that involves the transplant of intestinal microbiota from healthy donors into the patient\'s gastrointestinal tract to improve the gut microenvironment. In this case report, we describe the first case of adult AS treated with FMT. The patient suffered from diarrhea-predominant irritable bowel syndrome for 6 years with symptoms of diarrhea and abdominal pain. After three rounds of FMT, the diarrhea and abdominal pain were significantly improved. Moreover, the symptoms of AS were also significantly ameliorated. We found that FMT changed the structure of the intestinal microbiota as well as the patient\'s serum metabolites, and these changes were consistent with the patient\'s symptoms. The metabolites may affect signaling pathways, as revealed by Kyoto Encyclopedia of Genes and Genomes enrichment analysis. The changes in microbial metabolites following FMT may affect other regions (e.g., the nervous system) via the circulatory system, such that the bacteria-gut-blood-brain axis may be the means through which FMT mitigates AS.
摘要：
阿斯伯格综合征（AS）是一种慢性神经发育障碍。尽管所有临床诊断病例都显示正常的智力和言语功能，社会交往和沟通障碍严重影响心理健康和心理功能。除了传统的心理/行为训练和对症药物治疗，对肠道微生物群和心理健康的深入研究表明，益生菌(例如，鼠李糖乳杆菌)能有效减少AS的发生。粪便微生物移植（FMT）是一种生物治疗方法，涉及将健康供体的肠道微生物移植到患者的胃肠道中以改善肠道微环境。在这个案例报告中,我们描述了第一例接受FMT治疗的成人AS。该患者患有腹泻型肠易激综合征6年，症状为腹泻和腹痛。经过三轮FMT，腹泻和腹痛明显改善。此外，AS的症状也显著改善.我们发现FMT改变了肠道微生物群的结构以及患者的血清代谢产物,这些变化与患者的症状一致。代谢物可能会影响信号通路，正如京都基因百科全书和基因组富集分析所揭示的那样。FMT后微生物代谢物的变化可能会影响其他区域(例如，神经系统)通过循环系统，因此，细菌-肠道-血脑轴可能是FMT缓解AS的手段。
