PDF(Pubmed)
Abstract：
The study aimed to explore additive interactions of CDKAL1 rs7747752 and GUDCA/DCA for GDM risk and whether the interactive effects on the risk of GDM was mediated via increasing lysophosphatidylcholines (LPC) 18:0 and/or saturated fatty acid (SFA) 16:0.
A 1:1 age-matched study nested in a prospective cohort of pregnant women (207 pairs) was organized in Tianjin, China. Additive interactions were used to test interaction effects while mediation analyses and Sobel tests were used to test mediation effects of LPC18:0 and SFA16:0 between copresence of rs7747752 and low GUDCA/DCA, and GDM risk.
The CDKAL1 rs7747752 was associated with GDM (P<0.05). The rs7747752 C polymorphism markedly enhanced ORs of low GUDCA from 4.04 (0.72-22.8) to 9.02 (1.63-49.7) and low DCA from 1.67 (0.68-4.11) to 4.24 (1.84-9.76), both with significant additive interactions. Further adjustment for LPC18:0 attenuated the interactive effects of rs7747752 and low DCA, with a significant mediation effect (P=0.003). High SFA16:0 did not mediate the interactive effects of rs7747752 and low DCA/GUDCA on GDM risk.
The CDKAL1 rs7747752 C carrier status and low GUDCA/DCA had significant additive interactions on the risk of GDM with the effect from interaction with DCA being partially mediated via increasing LPC18:0.
A 1:1 age-matched study nested in a prospective cohort of pregnant women (207 pairs) was organized in Tianjin, China. Additive interactions were used to test interaction effects while mediation analyses and Sobel tests were used to test mediation effects of LPC18:0 and SFA16:0 between copresence of rs7747752 and low GUDCA/DCA, and GDM risk.
The CDKAL1 rs7747752 was associated with GDM (P<0.05). The rs7747752 C polymorphism markedly enhanced ORs of low GUDCA from 4.04 (0.72-22.8) to 9.02 (1.63-49.7) and low DCA from 1.67 (0.68-4.11) to 4.24 (1.84-9.76), both with significant additive interactions. Further adjustment for LPC18:0 attenuated the interactive effects of rs7747752 and low DCA, with a significant mediation effect (P=0.003). High SFA16:0 did not mediate the interactive effects of rs7747752 and low DCA/GUDCA on GDM risk.
The CDKAL1 rs7747752 C carrier status and low GUDCA/DCA had significant additive interactions on the risk of GDM with the effect from interaction with DCA being partially mediated via increasing LPC18:0.
摘要：
该研究旨在探讨CDKAL1rs7747752和GUDCA/DCA对GDM风险的累加相互作用，以及对GDM风险的相互作用是否通过增加溶血磷脂酰胆碱（LPC）18：0和/或饱和脂肪酸（SFA）16：0介导。
在天津组织了一项1：1年龄匹配的前瞻性孕妇队列研究（207对），中国。加性相互作用用于测试相互作用效果，而调解分析和Sobel测试用于测试rs7747752和低GUDCA/DCA之间的LPC18：0和SFA16：0的调解效果。GDM风险。
CDKAL1rs7747752与GDM相关(P<0.05)。rs7747752C多态性显着增强低GUDCA的OR从4.04（0.72-22.8）到9.02（1.63-49.7），低DCA从1.67（0.68-4.11）到4.24（1.84-9.76），两者都具有显著的加性相互作用。LPC18:0的进一步调整减弱了rs7747752和低DCA的交互影响，具有显著的中介效应(P=0.003)。高SFA16:0不介导rs7747752和低DCA/GUDCA对GDM风险的交互效应。
CDKAL1rs7747752C载体状态和低GUDCA/DCA对GDM的风险具有显著的加性相互作用，与DCA相互作用的影响部分通过增加LPC18:0介导。
在天津组织了一项1：1年龄匹配的前瞻性孕妇队列研究（207对），中国。加性相互作用用于测试相互作用效果，而调解分析和Sobel测试用于测试rs7747752和低GUDCA/DCA之间的LPC18：0和SFA16：0的调解效果。GDM风险。
CDKAL1rs7747752与GDM相关(P<0.05)。rs7747752C多态性显着增强低GUDCA的OR从4.04（0.72-22.8）到9.02（1.63-49.7），低DCA从1.67（0.68-4.11）到4.24（1.84-9.76），两者都具有显著的加性相互作用。LPC18:0的进一步调整减弱了rs7747752和低DCA的交互影响，具有显著的中介效应(P=0.003)。高SFA16:0不介导rs7747752和低DCA/GUDCA对GDM风险的交互效应。
CDKAL1rs7747752C载体状态和低GUDCA/DCA对GDM的风险具有显著的加性相互作用，与DCA相互作用的影响部分通过增加LPC18:0介导。
