PDF(Pubmed)
Abstract：
Biological weapons have been used for thousands of years, but recent advances in synthesis technologies have made peptide and protein toxin production more accessible and pose a threat to biosecurity worldwide. Natural toxins such as conotoxins, certain hemolytic compounds, and enterotoxins are peptide agents that can be synthesized in an environment with weak biosecurity measures and rudimentarily weaponized for limited use against smaller targets for lethal or nonlethal effects. Technological advances are changing the threat landscape around biological weapons and potentially facilitating a shift from state sponsored to more micro-level threats stemming from terror cells, insider threats, and lone wolf attacks. Here, we present the reader with an overview of the threat of peptide and protein toxins, provide examples of potent peptide toxins, and introduce capabilities of a proposed biosecurity program utilizing artificial intelligence that unifies commercial nucleotide and peptide synthesis vendors.
摘要：
生物武器已经使用了数千年,但是合成技术的最新进展使肽和蛋白质毒素的生产更容易获得，并对全球的生物安全构成威胁。天然毒素，如螺毒素，某些溶血化合物，和肠毒素是肽试剂，可以在生物安全措施薄弱的环境中合成，并在有限的用途上被武器化，以对抗较小的目标，具有致命或非致命的作用。技术进步正在改变围绕生物武器的威胁格局，并可能促进从国家赞助到更微观层面的威胁的转变，这些威胁源于恐怖细胞，内部威胁,和孤狼袭击。这里,我们向读者概述了肽和蛋白质毒素的威胁，提供强效肽毒素的例子，并引入利用人工智能的拟议生物安全计划的能力，该人工智能统一了商业核苷酸和肽合成供应商。
