Abstract：
The causative agents of leprosy are Mycobacterium leprae and M. lepromatosis. Mycobacterium lepromatosis was found in 2008 to cause diffuse lepromatous leprosy in Mexican patients. This study aimed to identify M. leprae and M. lepromatosis in paraffin-embedded skin samples from Caribbean patients with leprosy. A total of six skin samples were obtained from the Dominican Republic. All cases presented the multibacillary form; five were nodular lepromatous leprosy, and one was borderline lepromatous leprosy. All patients received multidrug therapy. Molecular identification was achieved using the M. leprae-specific repetitive element for M. leprae and the hemN gene for M. lepromatosis. Mycobacterium leprae was identified in two lepromatous leprosy cases, and one borderline lepromatous leprosy case; M. lepromatosis was found in one nodular lepromatous leprosy case. Both Mycobacterium species were present in two nodular lepromatous leprosy cases. This is the first report of M. lepromatosis in the Dominican Republic.
摘要：
麻风病的病原体是麻风分枝杆菌和麻风分枝杆菌。2008年发现麻风分枝杆菌在墨西哥患者中引起弥漫性麻风病。这项研究旨在鉴定加勒比海麻风病患者石蜡包埋的皮肤样本中的麻风分枝杆菌和麻风病分枝杆菌。从多米尼加共和国获得总共六个皮肤样品。所有病例均呈多杆菌形式；5例为结节性麻风病，一个是边缘麻风病。所有患者均接受多药治疗。使用麻风分枝杆菌的麻风分枝杆菌特异性重复元件和麻风分枝杆菌的hemN基因进行分子鉴定。在两例麻风病中发现了麻风分枝杆菌，和1例临界麻风病案；在1例结节性麻风病案中发现了麻风病案。两种分枝杆菌都存在于两个结节性麻风病中。这是多米尼加共和国的第一个报告。
