Abstract：
OBJECTIVE: We present two cases of triplet pregnancy with complete hydatidiform mole (CHM) in contrasting outcomes and discuss the complications of mothers and outcomes of fetuses through a literature review, raising an important issue on the management of this special pregnancy.
METHODS: We share our manage experience for two cases of triplet pregnancy with CHM and retrospectively analyze 18 similar pregnancies reported previously with different pregnancy outcomes.
RESULTS: In our cases, one case receiving Clomiphene ovulation induction delivered two live fetuses by cesarean section at 30+ weeks without GTN (gestational trophoblastic neoplasia), unfortunately, the other case following ICSI-ET terminated the pregnancy in the setting of complications at 18+ weeks without GTN. No severe complications were detected during pregnancy and no pGTD was developed after delivery in neither of the pregnant.
CONCLUSIONS: Co-existing complete hydatidiform mole in multiple pregnancies may become more common owing to the spreading use of ART. The decision for whether continue pregnancy depending on the personalized conditions including the complications of the pregnancy, the outcomes of the fetuses, the gestational age for delivery, and the potential progression of persistent gestational trophoblastic disease (pGTD). Furthermore, close monitor is necessary for the pregnant with triplet pregnancy with CHM who want to continue pregnancy.
METHODS: We share our manage experience for two cases of triplet pregnancy with CHM and retrospectively analyze 18 similar pregnancies reported previously with different pregnancy outcomes.
RESULTS: In our cases, one case receiving Clomiphene ovulation induction delivered two live fetuses by cesarean section at 30+ weeks without GTN (gestational trophoblastic neoplasia), unfortunately, the other case following ICSI-ET terminated the pregnancy in the setting of complications at 18+ weeks without GTN. No severe complications were detected during pregnancy and no pGTD was developed after delivery in neither of the pregnant.
CONCLUSIONS: Co-existing complete hydatidiform mole in multiple pregnancies may become more common owing to the spreading use of ART. The decision for whether continue pregnancy depending on the personalized conditions including the complications of the pregnancy, the outcomes of the fetuses, the gestational age for delivery, and the potential progression of persistent gestational trophoblastic disease (pGTD). Furthermore, close monitor is necessary for the pregnant with triplet pregnancy with CHM who want to continue pregnancy.
摘要：
目的：我们介绍了两例三胎妊娠伴完全葡萄胎（CHM）的对比结局，并通过文献综述讨论了母亲的并发症和胎儿的结局。在这种特殊怀孕的管理上提出了一个重要问题。
方法：我们分享了2例CHM三胎妊娠的管理经验，并回顾性分析了18例以前报告的相似妊娠，但妊娠结局不同。
结果：在我们的案例中，1例接受氯米芬促排卵的患者在30周以上通过剖宫产分娩了两个活胎，但没有GTN（妊娠滋养细胞瘤），不幸的是,ICSI-ET后的另一例在没有GTN的18周出现并发症的情况下终止了妊娠.在怀孕期间未检测到严重并发症，并且在两个孕妇分娩后均未出现pGTD。
结论：由于ART的广泛使用，多胎妊娠中并存的完全葡萄胎可能变得更加普遍。是否继续怀孕的决定取决于个性化的条件，包括怀孕的并发症，胎儿的结果，分娩的胎龄，以及持续性妊娠滋养细胞疾病（pGTD）的潜在进展。此外，密切监测是必要的三胎妊娠与CHM谁想要继续怀孕。
方法：我们分享了2例CHM三胎妊娠的管理经验，并回顾性分析了18例以前报告的相似妊娠，但妊娠结局不同。
结果：在我们的案例中，1例接受氯米芬促排卵的患者在30周以上通过剖宫产分娩了两个活胎，但没有GTN（妊娠滋养细胞瘤），不幸的是,ICSI-ET后的另一例在没有GTN的18周出现并发症的情况下终止了妊娠.在怀孕期间未检测到严重并发症，并且在两个孕妇分娩后均未出现pGTD。
结论：由于ART的广泛使用，多胎妊娠中并存的完全葡萄胎可能变得更加普遍。是否继续怀孕的决定取决于个性化的条件，包括怀孕的并发症，胎儿的结果，分娩的胎龄，以及持续性妊娠滋养细胞疾病（pGTD）的潜在进展。此外，密切监测是必要的三胎妊娠与CHM谁想要继续怀孕。
