We conducted a multihospital retrospective study of 867 patients with first-time proximal lower extremity DVT who had undergone testing for HT. Patients with and without HT were compared regarding their VTE recurrence risk via Kaplan-Meier and multivariable analysis.
HT was present in 166 patients (19%). The baseline characteristics were similar between the patients with HT and without HT. No significant difference was found in the recurrence rates between the two groups (HT, 17%; no HT, 15%; P = .345). A Kaplan-Meier survival analysis revealed no significant differences in VTE-free survival between the patients with and without HT (hazard ratio [HR], 1.19; 95% confidence interval [CI], 0.77-1.84; P = .421). On multivariable analysis, the presence of HT was not associated with recurrent VTE. A higher body mass index (HR, 1.06; 95% CI, 1.03-1.10; P = .004) and unprovoked DVT (HR, 2.48; 95% CI, 1.69-3.66; P < .001) were risk factors for recurrence.
HT had no significant impact on the recurrence risk for patients with first-time lower extremity DVT. HT test results would, thus, not be expected to change clinical management and should therefore not be requested routinely for patients with DVT.
我们进行了一项多医院回顾性研究,对867例首次接受HT检测的下肢近端DVT患者进行了回顾性研究。通过Kaplan-Meier和多变量分析比较有和无HT患者的VTE复发风险。
166例患者(19%)存在HT。HT患者和无HT患者的基线特征相似。两组复发率无显著差异(HT,17%;无HT,15%;P=.345)。Kaplan-Meier生存分析显示,有和没有HT的患者之间无VTE生存没有显着差异(风险比[HR],1.19;95%置信区间[CI],0.77-1.84;P=.421)。在多变量分析中,HT的存在与VTE复发无关.较高的体重指数(HR,1.06;95%CI,1.03-1.10;P=.004)和无端DVT(HR,2.48;95%CI,1.69-3.66;P<.001)是复发的危险因素。
HT对首次下肢DVT患者的复发风险无显著影响。HT测试结果会,因此,预计不会改变临床管理,因此DVT患者不应接受常规治疗.