Abstract：
OBJECTIVE: To assess volumetric tissue changes following combined surgical therapy of peri-implantitis over a follow-up period of 24 months.
METHODS: A total of 20 patients (n = 28 implants) were diagnosed with peri-implantitis and underwent access flap surgery, implantoplasty, and augmentative therapy at intrabony components (ie, combined therapy) using a natural bone mineral and a native collagen membrane. The peri-implant region of interest (ROI) was intraorally scanned pre-operatively (S0), and after 12 (S3) and 24 (S4) months. Digital files were superimposed for the assessment of volumetric changes between the referred time points. The change in thickness was assessed at a standardized ROI, segmented into two equidistant sections (ie, marginal and apical).
RESULTS: Peri-implant tissues exhibited a nonsignificant mean thickness loss of 0.16 (95% CI: -4 to 0.06) and 0.17 mm (95% CI: -0.05 to 0.4) at S3 and S4, respectively. S0-S3 dimensional thickness changes at marginal and apical areas were -0.24 (95% CI: -0.48 to 0.002) and -0.19 mm (95% CI: -0.36 to -0.2), respectively. Dimensional changes from S0 to S4 amounted to -0.22 mm (95% CI: -0.46 to 0.02) and -0.07 mm (95% CI: -0.09 to 0.2), respectively. The thickness changes at marginal and apical ROIs were significant from S0 to S3. Clinical parameters (ie, plaque index, bleeding on probing, and probing depth) significantly improved over the 24-month follow-up period. Linear regression analyses revealed no significant association between baseline bone loss (%), width of keratinized mucosa, and mucosal recession scores and thickness changes.
CONCLUSIONS: Peri-implant tissues revealed minor volumetric changes at 12 and 24 months after combined surgical therapy.
METHODS: A total of 20 patients (n = 28 implants) were diagnosed with peri-implantitis and underwent access flap surgery, implantoplasty, and augmentative therapy at intrabony components (ie, combined therapy) using a natural bone mineral and a native collagen membrane. The peri-implant region of interest (ROI) was intraorally scanned pre-operatively (S0), and after 12 (S3) and 24 (S4) months. Digital files were superimposed for the assessment of volumetric changes between the referred time points. The change in thickness was assessed at a standardized ROI, segmented into two equidistant sections (ie, marginal and apical).
RESULTS: Peri-implant tissues exhibited a nonsignificant mean thickness loss of 0.16 (95% CI: -4 to 0.06) and 0.17 mm (95% CI: -0.05 to 0.4) at S3 and S4, respectively. S0-S3 dimensional thickness changes at marginal and apical areas were -0.24 (95% CI: -0.48 to 0.002) and -0.19 mm (95% CI: -0.36 to -0.2), respectively. Dimensional changes from S0 to S4 amounted to -0.22 mm (95% CI: -0.46 to 0.02) and -0.07 mm (95% CI: -0.09 to 0.2), respectively. The thickness changes at marginal and apical ROIs were significant from S0 to S3. Clinical parameters (ie, plaque index, bleeding on probing, and probing depth) significantly improved over the 24-month follow-up period. Linear regression analyses revealed no significant association between baseline bone loss (%), width of keratinized mucosa, and mucosal recession scores and thickness changes.
CONCLUSIONS: Peri-implant tissues revealed minor volumetric changes at 12 and 24 months after combined surgical therapy.
摘要：
目的：评估种植体周围炎联合手术治疗后24个月随访期的体积组织变化。
方法：共有20例患者（n=28）被诊断为种植体周围炎，并接受了入路皮瓣手术，植入成形术,和增强术内成分的治疗(即，联合疗法）使用天然骨矿物质和天然胶原蛋白膜。术前（S0）口内扫描感兴趣的植入物周围区域（ROI），12(S3)和24(S4)个月后。叠加数字文件以评估参考时间点之间的体积变化。在标准化的ROI中评估厚度的变化，分段成两个等距的部分(即，边缘和顶端)。
结果：种植体周围组织在S3和S4分别表现出0.16（95％CI：-4至0.06）和0.17mm（95％CI：-0.05至0.4）的无显著性平均厚度损失。边缘和顶端区域的S0-S3尺寸厚度变化为-0.24（95％CI：-0.48至0.002）和-0.19mm（95％CI：-0.36至-0.2），分别。从S0到S4的尺寸变化总计为-0.22mm（95％CI：-0.46至0.02）和-0.07mm（95％CI：-0.09至0.2），分别。从S0到S3，边缘和顶端ROI的厚度变化显着。临床参数(即，菌斑指数,探查时出血,和探测深度）在24个月的随访期内明显改善。线性回归分析显示基线骨丢失(%)之间没有显著关联，角化粘膜宽度，粘膜凹陷评分和厚度变化。
结论：在联合手术治疗后12个月和24个月，种植体周围组织显示微小的体积变化。
方法：共有20例患者（n=28）被诊断为种植体周围炎，并接受了入路皮瓣手术，植入成形术,和增强术内成分的治疗(即，联合疗法）使用天然骨矿物质和天然胶原蛋白膜。术前（S0）口内扫描感兴趣的植入物周围区域（ROI），12(S3)和24(S4)个月后。叠加数字文件以评估参考时间点之间的体积变化。在标准化的ROI中评估厚度的变化，分段成两个等距的部分(即，边缘和顶端)。
结果：种植体周围组织在S3和S4分别表现出0.16（95％CI：-4至0.06）和0.17mm（95％CI：-0.05至0.4）的无显著性平均厚度损失。边缘和顶端区域的S0-S3尺寸厚度变化为-0.24（95％CI：-0.48至0.002）和-0.19mm（95％CI：-0.36至-0.2），分别。从S0到S4的尺寸变化总计为-0.22mm（95％CI：-0.46至0.02）和-0.07mm（95％CI：-0.09至0.2），分别。从S0到S3，边缘和顶端ROI的厚度变化显着。临床参数(即，菌斑指数,探查时出血,和探测深度）在24个月的随访期内明显改善。线性回归分析显示基线骨丢失(%)之间没有显著关联，角化粘膜宽度，粘膜凹陷评分和厚度变化。
结论：在联合手术治疗后12个月和24个月，种植体周围组织显示微小的体积变化。
