Abstract：
Chemotherapeutics play a significant role in the management of most brain tumors. First pass effect, systemic toxicity, and more importantly, the blood-brain barrier pose significant challenges to the success of chemotherapy. Over the last 80 years, different techniques of intraarterial chemotherapy delivery have been performed in many studies but failed to become standard of care. The purpose of this article is to review the history of intraarterial drug delivery and osmotic blood-brain barrier disruption, identify the challenges for clinical translation, and identify future directions for these approaches.
摘要：
化学疗法在大多数脑肿瘤的治疗中起着重要作用。第一遍效果，全身毒性，更重要的是,血脑屏障对化疗的成功带来重大挑战.在过去的80年里，不同的动脉内化疗技术已在许多研究中进行,但未能成为标准治疗.本文的目的是回顾动脉内药物递送和渗透性血脑屏障破坏的历史，确定临床翻译的挑战，并确定这些方法的未来方向。
