Abstract：
Heart disease, the leading cause of death worldwide, refers to various illnesses that affect heart structure and function. Specific abnormalities affecting cardiac muscle contractility and remodeling and common factors including oxidative stress, inflammation, and apoptosis underlie the pathogenesis of heart diseases. Epidemiology studies have associated green tea consumption with lower morbidity and mortality from cardiovascular diseases, including heart and blood vessel dysfunction. Among the various compounds found in green tea, catechins are believed to play a significant role in producing benefits to cardiovascular health. Comprehensive literature reviews have been published to summarize the tea catechins\' antioxidative, anti-inflammatory, and anti-apoptosis effects in various diseases, such as cardiovascular diseases, cancers, and metabolic diseases. However, recent studies on tea catechins, especially the most abundant (-)-Epigallocatechin-3-Gallate (EGCG), revealed their capabilities in regulating cardiac muscle contraction by directly altering myofilament Ca2+ sensitivity on force development and Ca2+ ion handling in cardiomyocytes under both physiological and pathological conditions. In vitro and in vivo data also demonstrated that green tea extract or EGCG protected or rescued cardiac function, independent of their well-known effects against oxidative stress and inflammation. This mini-review will focus on the specific effects of tea catechins on heart muscle contractility at the molecular and cellular level, revisit their effects on oxidative stress and inflammation in various heart diseases, and discuss EGCG\'s potential as one of the lead compounds for new drug discovery for heart diseases.
摘要：
心脏病,全世界的主要死因,是指影响心脏结构和功能的各种疾病。影响心肌收缩力和重塑的特定异常以及包括氧化应激在内的常见因素，炎症,细胞凋亡是心脏疾病发病机制的基础。流行病学研究表明，饮用绿茶与心血管疾病的发病率和死亡率较低有关。包括心脏和血管功能障碍。在绿茶中发现的各种化合物中，儿茶素被认为在心血管健康方面发挥重要作用。已经发表了全面的文献综述，总结了茶儿茶素的抗氧化作用，抗炎,以及在各种疾病中的抗凋亡作用，比如心血管疾病，癌症,和代谢性疾病。然而,最近对茶儿茶素的研究，尤其是最丰富的（-）-表没食子儿茶素-3-没食子酸酯（EGCG），揭示了它们通过在生理和病理条件下直接改变肌丝Ca2对力发育和心肌细胞Ca2离子处理的敏感性来调节心肌收缩的能力。体外和体内数据还表明，绿茶提取物或EGCG保护或挽救心脏功能，独立于它们对氧化应激和炎症的众所周知的作用。这篇小型综述将重点介绍茶儿茶素在分子和细胞水平上对心肌收缩性的具体影响，重新审视它们对各种心脏病的氧化应激和炎症的影响，并讨论EGCG作为心脏病新药发现的先导化合物之一的潜力。
