PDF(Pubmed)
Abstract：
Clopidogrel is an antiplatelet drug used for secondary prevention of myocardial infarction, and it is also used in patients with cerebrovascular ischemia. Patients with acute myocardial infarction tend to be on dual antiplatelet therapy for 12 months followed by aspirin lifelong to prevent the risk of stent thrombosis. The most common side effects of clopidogrel are bleeding, neutropenia, and rash; however, arthritis is also one of the rare side effects. We present a case of a 53-year-old patient who had a recent myocardial infarction and was commenced on dual antiplatelet therapy in the form of aspirin and clopidogrel. He started to have severe joint pain, particularly in his knees and shoulders, and was not able to mobilize anymore only three weeks after starting the medications. His clopidogrel was stopped and the patient showed dramatic improvement within three to four days after discontinuation with complete resolution one week later.
摘要：
氯吡格雷是一种抗血小板药物，用于心肌梗死的二级预防，它也用于脑血管缺血患者。急性心肌梗死患者倾向于接受12个月的双重抗血小板治疗，然后终身服用阿司匹林以防止支架血栓形成的风险。氯吡格雷最常见的副作用是出血,中性粒细胞减少症,和皮疹；然而，关节炎也是罕见的副作用之一。我们介绍了一例53岁的患者，该患者最近发生了心肌梗塞，并开始以阿司匹林和氯吡格雷的形式进行双重抗血小板治疗。他开始有严重的关节疼痛，尤其是他的膝盖和肩膀，并且在开始服药三周后就无法再动员。停止他的氯吡格雷，患者在停药后的三到四天内表现出明显改善，一周后完全缓解。
