Abstract：
Diet has been suggested to play a role in determining the age at natural menopause; however, the evidence is inconsistent.
We systematically reviewed and evaluated published research about associations between diet and onset of natural menopause (ONM).
We searched 6 databases (Medline, Embase, Cochrane, PubMed, Web of Science and Google Scholar) through January 21,2021 to identify prospective studies assessing the association between diet and ONM. Two independent reviewers extracted data using a predesigned data-collection form. Pooled hazard risks (HRs) were calculated using random effect models.
Of the 6,137 eligible references we reviewed, we included 15 articles in our final analysis. Those 15 articles included 91,554 women out of 298,413 who experienced natural menopause during follow-up. Overall, there were 89 food groups investigated, 38 macronutrients and micronutrients, and 6 dietary patterns. Among the food groups, higher intake of green and yellow vegetables was associated with earlier age of ONM, while high intakes of some dairy products, such as low-fat, skimmed milk, and low intake of alcohol were associated with a later onset. We observed no consistent association between macronutrient and micronutrient intake and ONM. Our results suggests that a vegetarian diet could be associated with early ONM; we did not observe any other consistent effect from other dietary patterns. Limitations included the number of studies, lack of replication studies and the research being of an observational nature; most studies (11/15) were at medium risk of bias.
Although some food items were associated with ONM, the overall evidence about associations between diet and ONM remains controversial. Prospero id: CRD42021232087.
We systematically reviewed and evaluated published research about associations between diet and onset of natural menopause (ONM).
We searched 6 databases (Medline, Embase, Cochrane, PubMed, Web of Science and Google Scholar) through January 21,2021 to identify prospective studies assessing the association between diet and ONM. Two independent reviewers extracted data using a predesigned data-collection form. Pooled hazard risks (HRs) were calculated using random effect models.
Of the 6,137 eligible references we reviewed, we included 15 articles in our final analysis. Those 15 articles included 91,554 women out of 298,413 who experienced natural menopause during follow-up. Overall, there were 89 food groups investigated, 38 macronutrients and micronutrients, and 6 dietary patterns. Among the food groups, higher intake of green and yellow vegetables was associated with earlier age of ONM, while high intakes of some dairy products, such as low-fat, skimmed milk, and low intake of alcohol were associated with a later onset. We observed no consistent association between macronutrient and micronutrient intake and ONM. Our results suggests that a vegetarian diet could be associated with early ONM; we did not observe any other consistent effect from other dietary patterns. Limitations included the number of studies, lack of replication studies and the research being of an observational nature; most studies (11/15) were at medium risk of bias.
Although some food items were associated with ONM, the overall evidence about associations between diet and ONM remains controversial. Prospero id: CRD42021232087.
摘要：
有人建议饮食在决定自然更年期的年龄方面发挥作用；然而，证据不一致。
我们系统地回顾和评估了已发表的关于饮食与自然更年期（ONM）之间关系的研究。
我们搜索了6个数据库(Medline，Embase,科克伦,PubMed,WebofScience和GoogleScholar）至2021年1月21日，以确定评估饮食与ONM之间关联的前瞻性研究。两个独立的审阅者使用预先设计的数据收集表单提取数据。使用随机效应模型计算集合危险风险(HR)。
在我们审查的6137份合格参考文献中，我们在最终分析中包括了15篇文章。这15篇文章包括在随访期间经历自然更年期的298,413名妇女中的91,554名妇女。总的来说,调查了89个食物组，38种常量营养素和微量营养素，和6种饮食模式。在食物群体中，绿色和黄色蔬菜的摄入量较高与ONM的年龄较早有关，虽然一些乳制品的摄入量很高，比如低脂肪，脱脂奶,酒精摄入量低与发病晚有关。我们观察到大量营养素和微量营养素摄入量与ONM之间没有一致的关联。我们的结果表明，素食可能与早期ONM有关；我们没有观察到其他饮食模式的任何其他一致效果。限制包括研究的数量，缺乏复制研究,且研究具有观察性;大多数研究(11/15)存在中等偏倚风险.
虽然有些食物与ONM有关，关于饮食与ONM之间关联的总体证据仍存在争议.Prosperoid:CRD42021232087。
我们系统地回顾和评估了已发表的关于饮食与自然更年期（ONM）之间关系的研究。
我们搜索了6个数据库(Medline，Embase,科克伦,PubMed,WebofScience和GoogleScholar）至2021年1月21日，以确定评估饮食与ONM之间关联的前瞻性研究。两个独立的审阅者使用预先设计的数据收集表单提取数据。使用随机效应模型计算集合危险风险(HR)。
在我们审查的6137份合格参考文献中，我们在最终分析中包括了15篇文章。这15篇文章包括在随访期间经历自然更年期的298,413名妇女中的91,554名妇女。总的来说,调查了89个食物组，38种常量营养素和微量营养素，和6种饮食模式。在食物群体中，绿色和黄色蔬菜的摄入量较高与ONM的年龄较早有关，虽然一些乳制品的摄入量很高，比如低脂肪，脱脂奶,酒精摄入量低与发病晚有关。我们观察到大量营养素和微量营养素摄入量与ONM之间没有一致的关联。我们的结果表明，素食可能与早期ONM有关；我们没有观察到其他饮食模式的任何其他一致效果。限制包括研究的数量，缺乏复制研究,且研究具有观察性;大多数研究(11/15)存在中等偏倚风险.
虽然有些食物与ONM有关，关于饮食与ONM之间关联的总体证据仍存在争议.Prosperoid:CRD42021232087。
