Abstract：
The adaptive immune system, along with the innate immune system, are the two main biological processes that protect an organism from pathogens. The adaptive immune system is characterized by the specificity and extreme diversity of its antigen receptors. These antigen receptors are the immunoglobulins (IG) or antibodies of the B cells and the T cell receptors (TR) of the T cells. The IG are proteins that have a dual role in immunity: they recognize antigens and trigger elimination mechanisms, to rid the body of foreign cells. The synthesis of the immunoglobulin heavy and light chains requires gene rearrangements at the DNA level in the IGH, IGK, and IGL loci. The rhesus monkey (Macaca mulatta) is one of the most widely used nonhuman primate species in biomedical research. In this manuscript, we provide a thorough analysis of the three IG loci of the Mmul_10 assembly of rhesus monkey, integrating IMGT previously existing data. Detailed characterization of IG genes includes their localization and position in the loci, the determination of the allele functionality, and the description of the regulatory elements of their promoters as well as the sequences of the conventional recombination signals (RS). This complete annotation of the genomic IG loci of Mmul_10 assembly and the highly detailed IG gene characterization could be used as a model, in additional rhesus monkey assemblies, for the analysis of the IG allelic polymorphism and structural variation, which have been described in rhesus monkeys.
摘要：
适应性免疫系统,以及先天免疫系统，是保护生物体免受病原体侵害的两个主要生物过程。适应性免疫系统的特征在于其抗原受体的特异性和极端多样性。这些抗原受体是B细胞的免疫球蛋白(IG)或抗体以及T细胞的T细胞受体(TR)。IG是在免疫中具有双重作用的蛋白质：它们识别抗原并触发消除机制，清除体内的外来细胞.免疫球蛋白重链和轻链的合成需要IGH中DNA水平的基因重排,IGK,和IGL基因座。恒河猴（Macacamulatta）是生物医学研究中使用最广泛的非人灵长类动物之一。在这份手稿中,我们对恒河猴Mmul_10组装的三个IG基因座进行了全面分析，集成IMGT以前现有的数据。IG基因的详细表征包括它们在基因座中的定位和位置，等位基因功能的确定，和它们的启动子的调节元件的描述以及常规重组信号(RS)的序列。Mmul_10组装的基因组IG基因座的完整注释和高度详细的IG基因表征可以作为模型，在其他恒河猴集会中，用于分析IG等位基因多态性和结构变异，这在恒河猴身上有描述。
