Abstract：
Although delayed cerebral ischemia (DCI) commonly complicates recovery in survivors of aneurysmal subarachnoid hemorrhage (aSAH), its pathophysiology is incompletely understood. Previous studies examining the association of DCI and platelet count have demonstrated contradictory results. This study aimed to investigate this association in a cohort of aSAH patients using the 2010 consensus definition of DCI.
We conducted a retrospective single-center observational study of consecutive adult aSAH patients admitted to the intensive care unit from January 2010 to December 2014. Platelet count and DCI evaluations were performed daily in the first 14 days after admission. DCI was defined according to the 2010 consensus criteria.
A total of 340 patients were included for analysis. DCI incidence was 37.1%. Platelet count was not significantly associated with occurrence of DCI on any day. Mean platelet count was lowest on day 3 after aSAH and then increased to exceed the count at admission on day 6. Treatment modality and use of dual antiplatelet therapy were not associated with DCI.
Platelet count was not associated with DCI as defined by the 2010 consensus criteria. Future studies adhering to the 2010 consensus definition of DCI are needed to clarify the role of platelets and platelet function in DCI pathophysiology.
We conducted a retrospective single-center observational study of consecutive adult aSAH patients admitted to the intensive care unit from January 2010 to December 2014. Platelet count and DCI evaluations were performed daily in the first 14 days after admission. DCI was defined according to the 2010 consensus criteria.
A total of 340 patients were included for analysis. DCI incidence was 37.1%. Platelet count was not significantly associated with occurrence of DCI on any day. Mean platelet count was lowest on day 3 after aSAH and then increased to exceed the count at admission on day 6. Treatment modality and use of dual antiplatelet therapy were not associated with DCI.
Platelet count was not associated with DCI as defined by the 2010 consensus criteria. Future studies adhering to the 2010 consensus definition of DCI are needed to clarify the role of platelets and platelet function in DCI pathophysiology.
摘要：
尽管迟发性脑缺血（DCI）通常会使动脉瘤性蛛网膜下腔出血（aSAH）幸存者的康复复杂化，其病理生理学尚未完全了解。以前的研究检查DCI和血小板计数的相关性已经证明了矛盾的结果。本研究旨在使用2010年DCI的共识定义来调查aSAH患者队列中的这种关联。
我们对2010年1月至2014年12月入住重症监护病房的连续成人aSAH患者进行了回顾性单中心观察性研究。在入院后的前14天每天进行血小板计数和DCI评估。DCI是根据2010年共识标准定义的。
共纳入340名患者进行分析。DCI发生率为37.1%。血小板计数与任何一天的DCI的发生都没有显着相关。平均血小板计数在aSAH后第3天最低，然后在第6天增加到超过入院时的计数。治疗方式和双重抗血小板治疗的使用与DCI无关。
根据2010年共识标准的定义，血小板计数与DCI无关。需要遵循2010年DCI共识定义的未来研究来阐明血小板和血小板功能在DCI病理生理学中的作用。
我们对2010年1月至2014年12月入住重症监护病房的连续成人aSAH患者进行了回顾性单中心观察性研究。在入院后的前14天每天进行血小板计数和DCI评估。DCI是根据2010年共识标准定义的。
共纳入340名患者进行分析。DCI发生率为37.1%。血小板计数与任何一天的DCI的发生都没有显着相关。平均血小板计数在aSAH后第3天最低，然后在第6天增加到超过入院时的计数。治疗方式和双重抗血小板治疗的使用与DCI无关。
根据2010年共识标准的定义，血小板计数与DCI无关。需要遵循2010年DCI共识定义的未来研究来阐明血小板和血小板功能在DCI病理生理学中的作用。
