Abstract：
Symptom overlap between meibomian gland dysfunction (MGD) and dry eye (DE) makes it difficult to distinguish between these two conditions on the basis of symptoms alone. We searched for characteristic symptoms that might help to distinguish MGD from DE on the basis of a population-based study. Subjects comprised 311 residents of Takushima island (18 to 96 years), including 117 individuals with MGD and 114 with DE. Responses to a symptom-related questionnaire (19 items) were subjected to factor analysis, and univariate regression analysis was performed to identify ocular surface parameters associated with characteristic symptoms of MGD. Factor analysis revealed aggregation of symptoms according to three factors: Factor 1 related to Symptom Score, Factor 2 to DE, and Factor 3 to MGD. Symptoms associated with DE included 11 items, whereas the only item related to MGD was tearing sensation. Pearson\'s correlation analysis revealed that tearing sensation was associated with tear meniscus height (TMH), noninvasive tear-film breakup time, fluorescein staining score, meiboscore, meibum grade, and Schirmer value. Subjects with MGD experienced significantly more tearing and had a larger TMH than did those without MGD (p = 0.0334). Tearing sensation may thus be a characteristic symptom of MGD. Physicians should suspect MGD who complain of tearing sensation.
摘要：
睑板腺功能障碍（MGD）和干眼（DE）之间的症状重叠使得难以仅根据症状来区分这两种情况。我们在一项基于人群的研究的基础上，寻找可能有助于区分MGD和DE的特征性症状。受试者包括高岛岛的311名居民（18至96岁），包括117名MGD患者和114名DE患者。对症状相关问卷(19项)的反应进行因子分析，并进行单因素回归分析以确定与MGD特征性症状相关的眼表参数。因子分析显示症状根据三个因素聚集：与症状评分相关的因素1，因子2到DE，和因素3到MGD。与DE相关的症状包括11项，而与MGD相关的唯一项目是撕裂感。Pearson的相关分析显示，撕裂感与撕裂半月板高度（TMH）有关，非侵入性泪膜破裂时间，荧光素染色评分,meibocore,美布等级,和Schirmer值。患有MGD的受试者比没有MGD的受试者经历了明显更多的撕裂并且具有更大的TMH(p=0.0334)。因此撕裂感可能是MGD的特征性症状。医师应怀疑MGD抱怨撕裂感。
