Abstract：
BACKGROUND: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. However, no prospective longitudinal studies directly comparing the performance of equations for estimating GFR in this patient population currently exist.
METHODS: In total, 32 patients undergoing LTx met the study criteria. At pre-LTx and 1-, 3-, and 12-weeks post-LTx, GFR was determined by 51Cr-EDTA and by equations for estimating GFR based on plasma (P)-Creatinine, P-Cystatin C, or a combination of both.
RESULTS: Measured GFR declined from 98.0 mL/min/1.73 m2 at pre-LTx to 54.1 mL/min/1.73 m2 at 12-weeks post-LTx. Equations based on P-Creatinine underestimated GFR decline after LTx, whereas equations based on P-Cystatin C overestimated this decline. Overall, the 2021 CKD-EPI combination equation had the lowest bias and highest precision at both pre-LTx and post-LTx.
CONCLUSIONS: Caution must be applied when interpreting renal function based on equations for estimating GFR in the acute postoperative period following LTx. Simplified methods for measuring GFR may allow for more widespread use of measured GFR in this vulnerable patient population.
METHODS: In total, 32 patients undergoing LTx met the study criteria. At pre-LTx and 1-, 3-, and 12-weeks post-LTx, GFR was determined by 51Cr-EDTA and by equations for estimating GFR based on plasma (P)-Creatinine, P-Cystatin C, or a combination of both.
RESULTS: Measured GFR declined from 98.0 mL/min/1.73 m2 at pre-LTx to 54.1 mL/min/1.73 m2 at 12-weeks post-LTx. Equations based on P-Creatinine underestimated GFR decline after LTx, whereas equations based on P-Cystatin C overestimated this decline. Overall, the 2021 CKD-EPI combination equation had the lowest bias and highest precision at both pre-LTx and post-LTx.
CONCLUSIONS: Caution must be applied when interpreting renal function based on equations for estimating GFR in the acute postoperative period following LTx. Simplified methods for measuring GFR may allow for more widespread use of measured GFR in this vulnerable patient population.
摘要：
背景：接受肺移植（LTx）的患者在急性术后期间肾小球滤过率（GFR）迅速下降。然而,目前尚无前瞻性纵向研究直接比较该患者人群GFR估算方程的性能.
方法：总共，32例接受LTx的患者符合研究标准。在pre-LTx和1-，3-,LTx后12周，通过51Cr-EDTA和基于血浆（P）-肌酸酐的估算GFR的方程式测定GFR，P-胱抑素C,或两者的组合。
结果：测得的GFR从LTx前的98.0mL/min/1.73m2下降到LTx后12周的54.1mL/min/1.73m2。基于P-肌酸酐的方程低估了LTx后GFR的下降，而基于P-胱抑素C的方程高估了这种下降。总的来说,2021年CKD-EPI组合方程在LTx前和LTx后的偏差最低,精度最高.
结论：在基于估算LTx术后急性期GFR的方程解释肾功能时，必须谨慎。用于测量GFR的简化方法可以允许在该脆弱患者群体中更广泛地使用测量的GFR。
方法：总共，32例接受LTx的患者符合研究标准。在pre-LTx和1-，3-,LTx后12周，通过51Cr-EDTA和基于血浆（P）-肌酸酐的估算GFR的方程式测定GFR，P-胱抑素C,或两者的组合。
结果：测得的GFR从LTx前的98.0mL/min/1.73m2下降到LTx后12周的54.1mL/min/1.73m2。基于P-肌酸酐的方程低估了LTx后GFR的下降，而基于P-胱抑素C的方程高估了这种下降。总的来说,2021年CKD-EPI组合方程在LTx前和LTx后的偏差最低,精度最高.
结论：在基于估算LTx术后急性期GFR的方程解释肾功能时，必须谨慎。用于测量GFR的简化方法可以允许在该脆弱患者群体中更广泛地使用测量的GFR。
