Abstract：
The inductive effect of hyalinisation and its influence on the biologic behaviour of ameloblastoma variants represent a scarcely researched domain of oral pathology. The complexity of the induction effects within the odontogenic apparatus, with the involvement of both ectodermal and mesodermal tissues, is responsible for diverse histopathological characteristics, hyalinisation being the major feature. The present study aims to deduce for the first time the correlation between the severity of hyalinisation (SOH) and recurrence in three unicystic ameloblastoma (UA) variants, namely, intra-luminal (UA-IL), luminal (UA-L) and mural (UA-M). Retrospectively diagnosed archival cases of UA-IL (n = 08), UA-L (n = 22) and UA-M (n = 30) were assessed for SOH and its correlation with recurrence. A subgroup comparison (between UA-IL/UA-L and UA-M) was also performed. The clinical parameters of the patients were also analysed from files for clinicopathological correlation with recurrence. Results: sub-epithelial hyalinisation (SEH) significantly correlated with the recurrence of UA-L and UA-M (p = 0.001). When the histologic types (UA-L and UA-IL vs. UA-M) were grouped and the correlation of SOH with recurrence was checked, it was observed that both groups (p = 0.001) showed strong statistical correlation. UA-M lesions with multilocular radiolucency (p = 0.001) also showed significant correlation with recurrence. SOH can be a reliable histological predictor of recurrence and of aggressive biologic behaviour in UA. The present study shows a significant association of hyalinisation with the biologic behaviour of UA. Further studies with immunohistochemical investigations could validate the presence of hyalinisation and identify the origin of the hyalinised product in UAs.
摘要：
透明化的诱导作用及其对成釉细胞瘤变体的生物学行为的影响代表了口腔病理学的一个几乎没有研究的领域。牙源性设备内诱导效应的复杂性，外胚层和中胚层组织都参与其中，负责不同的组织病理学特征，透明质化是主要特征。本研究旨在首次推断三种单囊性成釉细胞瘤（UA）变种的透明质化（SOH）严重程度与复发之间的相关性。即,腔内（UA-IL），腔（UA-L）和壁（UA-M）。回顾性诊断的UA-IL档案病例（n=08），评估UA-L（n=22）和UA-M（n=30）的SOH及其与复发的相关性。还进行了亚组比较（UA-IL/UA-L和UA-M之间）。还从文件中分析了患者的临床参数与复发的临床病理相关性。结果：上皮下透明化（SEH）与UA-L和UA-M的复发显着相关（p=0.001）。当组织学类型(UA-L和UA-ILvs.对UA-M）进行分组，并检查SOH与复发的相关性，观察到两组(p=0.001)显示出强的统计学相关性.UA-M病变与多房性放射性（p=0.001）也显示出与复发的显着相关性。SOH可以是UA复发和侵袭性生物学行为的可靠组织学预测指标。本研究表明，透明质化与UA的生物学行为存在显着关联。通过免疫组织化学研究的进一步研究可以验证透明质化的存在并确定透明质化产物在UA中的起源。
