Abstract：
The objective of this study was to compare immediate intramammary antimicrobial treatment of mild and moderate cases of clinical mastitis (CM) with a selective treatment protocol based on on-farm culture results using Accumast®. The study was conducted at a 2600 cow commercial farm in Northeast Germany. Using a randomized design, mild and moderate clinical mastitis cases were assigned to either the blanket therapy (BT) or pathogen-based therapy (SELECT) group. Overall, 468 cases were used for final analyses (BT = 236; SELECT = 232). The percentage of cases assigned to the blanket and pathogen-based groups that received intramammary therapy were 100 and 69.9%, respectively. Implementation of a pathogen-based treatment protocol for mild and moderate CM cases resulted in no significant difference in post-event milk production, somatic cell count, survival to 30 d, and days spent in the hospital compared with a blanket therapy protocol. Cows in the SELECT group had reduced odds of being culled within 60 d post CM (odds ratio = 0.54; 95% CI = 0.31-0.93; p = 0.027). The use of a pathogen-based treatment protocol using an on-farm culture system has the potential to efficiently reduce antimicrobial use without negative effects on health.
摘要：
这项研究的目的是比较轻度和中度临床乳腺炎（CM）病例的即时乳房内抗微生物治疗与基于使用Accumast®的农场培养结果的选择性治疗方案。该研究是在德国东北部的2600头牛商业农场进行的。使用随机设计，轻度和中度临床乳腺炎病例被分配到一揽子治疗(BT)或基于病原体的治疗(SELECT)组.总的来说,最终分析为468例（BT=236；SELECT=232）。分配到接受乳房内治疗的毯子和基于病原体组的病例百分比分别为100和69.9％，分别。对轻度和中度CM病例实施基于病原体的治疗方案没有导致事件后产奶量的显著差异。体细胞计数,存活到30d，与一揽子治疗方案相比，在医院度过的天数。选择组的奶牛在CM后60d内被淘汰的几率降低(比值比=0.54;95%CI=0.31-0.93;p=0.027)。使用农场培养系统的基于病原体的治疗方案的使用具有有效减少抗微生物剂使用而不对健康产生负面影响的潜力。
