Abstract：
Digital polymers with precisely arranged binary units provide an important option for information storage. This is especially true if the digital polymers are assembled in a device, as it would be of great benefit for data writing and reading in practice. Herein, inspired by the DNA microarray technique, the programmable information storing and reading on a mass spectrometry target plate is proposed. First, an array of 4-bit sequence-coded dithiosuccinimide oligomers is efficiently built through sequential thiol-maleimide Michael couplings with good sequence readability by tandem mass spectrometry (MS/MS). Then, toward engineering microarrays for information storage, a programmed robotic arm is specifically designed for precisely loading sequence-coded oligomers onto the target plate, and a decoding software is developed for efficient readout of the data from MS/MS sequencing. Notably, short sequence-coded oligomer chains can be used to write long strings of information, and extra error-correction codes are not required as usual due to the inherent concomitant fragmentation signals. Not only text but also bitimages can be automatically stored and decoded with excellent accuracy. This work provides a promising platform of digital polymers for programmable information storing and reading.
摘要：
具有精确排列的二元单元的数字聚合物为信息存储提供了重要的选择。如果数字聚合物组装在设备中，尤其如此，因为这将是非常有益的数据写入和读取在实践中。在这里，受到DNA微阵列技术的启发，提出了在质谱靶板上进行可编程信息存储和读取的方法。首先,4位序列编码的二硫代琥珀酰亚胺低聚物的阵列通过串联质谱(MS/MS)通过具有良好序列可读性的顺序硫醇-马来酰亚胺迈克尔偶联有效地构建。然后，用于信息存储的工程微阵列，一个编程的机械臂是专门设计用于精确加载序列编码的低聚物到目标板上，并且开发了用于从MS/MS测序中有效读出数据的解码软件。值得注意的是,短序列编码的寡聚体链可用于写入信息的长字符串，和额外的纠错码通常不需要由于固有的伴随分段信号。不仅文本，而且还可以自动存储和解码具有出色的准确性。这项工作为可编程信息存储和读取提供了一个有前途的数字聚合物平台。
