Abstract：
Staphylococcus aureus is a common gram-positive human pathogen involved in both community-acquired and nosocomial infections ranging from localised superficial lesions to food poisoning and fatal systemic infections owing to its impressive array of virulence factors responsible for attaching, colonising, invading, and avoiding host immune system. The discovery of antibiotics effectively checked the once deadly infections. However, resistance started soon after their discovery and the first methicillin-resistant strain of staphylococcus aureus was reported in the early 1960s. The most important attribute of methicillin-resistant staphylococcus aureus is its acquisition of mecA gene coding for penicillin-binding protein-2a that blocks inhibitory action on peptidoglycan cross-linking. Methicillin-resistant staphylococcus aureus presents a serious global healthcare concern being responsible for prolonged hospital stays and increased mortality. The precise information of virulence factors and resistant traits of methicillin-resistant staphylococcus aureus and their interplay in a community is key to minimize the intermixing of resistant and susceptible pathogens in the community.
摘要：
金黄色葡萄球菌是一种常见的革兰氏阳性人类病原体，涉及社区获得性和医院感染，范围从局部浅表病变到食物中毒和致命的全身性感染，因为它具有令人印象深刻的毒力因子，殖民,入侵,避免宿主免疫系统。抗生素的发现有效地遏制了曾经致命的感染。然而,耐药性在发现后不久就开始出现，1960年代初报道了第一株耐甲氧西林金黄色葡萄球菌菌株。耐甲氧西林金黄色葡萄球菌最重要的属性是它获得了编码青霉素结合蛋白-2a的mecA基因，该基因阻断了对肽聚糖交联的抑制作用。耐甲氧西林金黄色葡萄球菌是一个严重的全球医疗保健问题，导致住院时间延长和死亡率增加。社区中耐甲氧西林金黄色葡萄球菌的毒力因子和耐药特性及其相互作用的准确信息是最大程度地减少社区中耐药和易感病原体混合的关键。
