PDF(Pubmed)
Abstract：
Urine protein electrophoresis is often required for diagnosis and monitoring of urological or renal diseases and lymphoid hemopathies. We here report an uncommon urine protein electrophoresis result. The test was performed using agarose gel electrophoresis and capillary electrophoresis. It was a monoclonal peak of unknown significance migrating with gammaglobulins. Scientific literature and the tests performed demonstrated that it was myoglobin. In fact, myoglobin (17 kDa) is freely filtered by the glomerulus and normally reabsorbed by the tubules. If tubule capacity for reabsorption is exceeded, its presence results in overcharging proteinuria. Myoglobinuria helped diagnose rhabdomyolysis in our patient. Thus, the analysis of unknown peaks, can provide information on symptoms but also underlying pathologies, which may be of clinical interest.
摘要：
尿蛋白电泳通常需要诊断和监测泌尿系统或肾脏疾病以及淋巴样血液病。我们在这里报告了一种罕见的尿蛋白电泳结果。使用琼脂糖凝胶电泳和毛细管电泳进行测试。这是一个未知意义的单克隆峰，与丙种球蛋白一起迁移。科学文献和进行的测试表明它是肌红蛋白。事实上,肌红蛋白（17kDa）被肾小球自由过滤，通常被小管重新吸收。如果超过了小管的再吸收能力，它的存在导致过度充电的蛋白尿。肌红蛋白尿症有助于我们患者的横纹肌溶解症的诊断。因此，对未知峰的分析，可以提供症状信息，也可以提供潜在的病理信息，这可能是临床上感兴趣的。
