Abstract：
Headaches with marked, specific response to indomethacin occur in children, but the phenotypic spectrum of this phenomenon has not been well-studied.
We reviewed pediatric patients with headache showing ≥80% improvement with indomethacin, from seven academic medical centers.
We included 32 pediatric patients (16 females). Mean headache onset age was 10.9 y (range 2-16 y). Headache syndromes included hemicrania continua (n = 13), paroxysmal hemicrania (n = 10), primary stabbing headache (n = 2), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (n = 1), primary exercise headache (n = 1) and primary cough headache (n = 1). Adverse events were reported in 13, most commonly gastrointestinal symptoms, which often improved with co-administration of gastro-protective agents.
Indomethacin-responsive headaches occur in children and adolescents, and include headache syndromes, such as primary cough headache, previously thought to present only in adulthood. The incidence of adverse events is high, and patients must be co-treated with a gastroprotective agent.
We reviewed pediatric patients with headache showing ≥80% improvement with indomethacin, from seven academic medical centers.
We included 32 pediatric patients (16 females). Mean headache onset age was 10.9 y (range 2-16 y). Headache syndromes included hemicrania continua (n = 13), paroxysmal hemicrania (n = 10), primary stabbing headache (n = 2), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (n = 1), primary exercise headache (n = 1) and primary cough headache (n = 1). Adverse events were reported in 13, most commonly gastrointestinal symptoms, which often improved with co-administration of gastro-protective agents.
Indomethacin-responsive headaches occur in children and adolescents, and include headache syndromes, such as primary cough headache, previously thought to present only in adulthood. The incidence of adverse events is high, and patients must be co-treated with a gastroprotective agent.
摘要：
带有标记的头痛，对吲哚美辛的特异性反应发生在儿童中，但是这种现象的表型谱还没有得到很好的研究。
我们回顾了消炎痛改善≥80%的小儿头痛患者，来自七个学术医疗中心。
我们纳入了32名儿科患者（16名女性）。平均头痛发病年龄为10.9岁（范围2-16岁）。头痛综合征包括连续性偏头痛（n=13），阵发性偏头痛（n=10），原发性刺伤性头痛（n=2），伴有结膜注射和撕裂的短期单侧神经性头痛发作（n=1），原发性运动头痛（n=1）和原发性咳嗽头痛（n=1）。不良事件报告13例，最常见的胃肠道症状，通常与胃保护剂的共同给药改善。
吲哚美辛反应性头痛发生在儿童和青少年，包括头痛综合征，如原发性咳嗽头痛，以前认为只在成年期出现。不良事件发生率高,患者必须用胃保护剂共同治疗。
我们回顾了消炎痛改善≥80%的小儿头痛患者，来自七个学术医疗中心。
我们纳入了32名儿科患者（16名女性）。平均头痛发病年龄为10.9岁（范围2-16岁）。头痛综合征包括连续性偏头痛（n=13），阵发性偏头痛（n=10），原发性刺伤性头痛（n=2），伴有结膜注射和撕裂的短期单侧神经性头痛发作（n=1），原发性运动头痛（n=1）和原发性咳嗽头痛（n=1）。不良事件报告13例，最常见的胃肠道症状，通常与胃保护剂的共同给药改善。
吲哚美辛反应性头痛发生在儿童和青少年，包括头痛综合征，如原发性咳嗽头痛，以前认为只在成年期出现。不良事件发生率高,患者必须用胃保护剂共同治疗。
