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Abstract：
Peripheral nerve injury (PNI) is a common disease in clinic, and the regeneration process of peripheral nerve tissue is slow, and patients with PNI often suffer from the loss of nerve function. At present, related research on the mechanism of peripheral nerve regeneration has become a hot spot, and scholars are also seeking a method that can accelerate the regeneration of peripheral nerve. Platelet-rich plasma (PRP) is a platelet concentrate extracted from autologous blood by centrifugation, which is a kind of bioactive substance. High concentration of platelets can release a variety of growth factors after activation, and can promote the proliferation and differentiation of tissue cells, which can accelerate the process of tissue regeneration. The application of PRP comes from the body, there is no immune rejection reaction, it can promote tissue regeneration with less cost, it is,therefore, widely used in various clinical fields. At present, there are relatively few studies on the application of PRP to peripheral nerve regeneration. This article summarizes the literature in recent years to illustrate the effect of PRP on peripheral nerve regeneration from mechanism to clinical application, and prospects for the application of PRP to peripheral nerve.
摘要：
周围神经损伤(PNI)是临床常见病,周围神经组织的再生过程缓慢，PNI患者常出现神经功能丧失。目前,周围神经再生机制的相关研究已成为热点,学者们也在寻求一种可以加速周围神经再生的方法。富血小板血浆（PRP）是通过离心从自体血液中提取的血小板浓缩物，这是一种生物活性物质。高浓度的血小板活化后可释放多种生长因子，能促进组织细胞的增殖和分化，可以加速组织再生的过程。PRP的应用来自身体，没有免疫排斥反应,它可以促进组织再生，成本较低，它是,因此,广泛应用于临床各个领域。目前,关于PRP在周围神经再生中应用的研究相对较少。本文对近年来的文献进行综述,阐述PRP对周围神经再生的作用,从机制到临床应用,并展望了PRP在周围神经中的应用前景。
