PDF(Pubmed)
Abstract：
BACKGROUND: Recent studies have investigated dogs with presumed diet-associated dilated cardiomyopathy (daDCM), but prospective studies of multiple breeds are needed.
OBJECTIVE: To evaluate baseline features and serial changes in echocardiography and cardiac biomarkers in dogs with DCM eating nontraditional diets (NTDs) or traditional diets (TDs), and in dogs with subclinical cardiac abnormalities (SCA) eating NTD.
METHODS: Sixty dogs with DCM (NTD, n = 51; TDs, n = 9) and 16 dogs with SCA eating NTDs.
METHODS: Echocardiography, electrocardiography, and measurement of taurine, cardiac troponin I, and N-terminal pro-B-type natriuretic peptide were performed in dogs with DCM or SCA. Diets were changed for all dogs, taurine was supplemented in most, and echocardiography and cardiac biomarkers were reassessed (3, 6, and 9 months).
RESULTS: At enrollment, there were few differences between dogs with DCM eating NTDs or TDs; none had low plasma or whole blood taurine concentrations. Improvement in fractional shortening over time was significantly associated with previous consumption of a NTD, even after adjustment for other variables (P = .005). Median survival time for dogs with DCM was 611 days (range, 2-940 days) for the NTD group and 161 days (range, 12-669 days) for the TD group (P = .21). Sudden death was the most common cause of death in both diet groups. Dogs with SCA also had significant echocardiographic improvements over time.
CONCLUSIONS: Dogs with DCM or SCA previously eating NTDs had small, yet significant improvements in echocardiographic parameters after diet changes.
OBJECTIVE: To evaluate baseline features and serial changes in echocardiography and cardiac biomarkers in dogs with DCM eating nontraditional diets (NTDs) or traditional diets (TDs), and in dogs with subclinical cardiac abnormalities (SCA) eating NTD.
METHODS: Sixty dogs with DCM (NTD, n = 51; TDs, n = 9) and 16 dogs with SCA eating NTDs.
METHODS: Echocardiography, electrocardiography, and measurement of taurine, cardiac troponin I, and N-terminal pro-B-type natriuretic peptide were performed in dogs with DCM or SCA. Diets were changed for all dogs, taurine was supplemented in most, and echocardiography and cardiac biomarkers were reassessed (3, 6, and 9 months).
RESULTS: At enrollment, there were few differences between dogs with DCM eating NTDs or TDs; none had low plasma or whole blood taurine concentrations. Improvement in fractional shortening over time was significantly associated with previous consumption of a NTD, even after adjustment for other variables (P = .005). Median survival time for dogs with DCM was 611 days (range, 2-940 days) for the NTD group and 161 days (range, 12-669 days) for the TD group (P = .21). Sudden death was the most common cause of death in both diet groups. Dogs with SCA also had significant echocardiographic improvements over time.
CONCLUSIONS: Dogs with DCM or SCA previously eating NTDs had small, yet significant improvements in echocardiographic parameters after diet changes.
摘要：
背景：最近的研究调查了患有假定饮食相关扩张型心肌病（daDCM）的狗，但需要对多个品种进行前瞻性研究.
目的：评估服用非传统饮食（NTDs）或传统饮食（TDs）的DCM犬的超声心动图和心脏生物标志物的基线特征和系列变化，以及在患有亚临床心脏异常（SCA）的狗中食用NTD。
方法：60只DCM犬（NTD，n=51；TD，n=9）和16只SCA吃NTDs的狗。
方法：超声心动图，心电图,和牛磺酸的测量，心肌肌钙蛋白I,在患有DCM或SCA的狗中进行N末端B型利钠肽前体。所有狗的饮食都改变了，牛磺酸在大多数补充，超声心动图和心脏生物标志物被重新评估(3,6和9个月).
结果：在注册时，服用NTDs或TDs的DCM犬之间几乎没有差异;没有人的血浆或全血牛磺酸浓度低。随着时间的推移，缩短分数的改善与NTD的先前消耗显着相关，即使在对其他变量进行调整后(P=0.005)。患有DCM的狗的中位生存时间为611天（范围，NTD组的2-940天)和161天(范围，TD组12-669天）（P=.21）。猝死是两个饮食组中最常见的死亡原因。随着时间的推移，患有SCA的狗也有明显的超声心动图改善。
结论：先前食用NTDs的患有DCM或SCA的狗，然而，饮食改变后超声心动图参数显著改善。
目的：评估服用非传统饮食（NTDs）或传统饮食（TDs）的DCM犬的超声心动图和心脏生物标志物的基线特征和系列变化，以及在患有亚临床心脏异常（SCA）的狗中食用NTD。
方法：60只DCM犬（NTD，n=51；TD，n=9）和16只SCA吃NTDs的狗。
方法：超声心动图，心电图,和牛磺酸的测量，心肌肌钙蛋白I,在患有DCM或SCA的狗中进行N末端B型利钠肽前体。所有狗的饮食都改变了，牛磺酸在大多数补充，超声心动图和心脏生物标志物被重新评估(3,6和9个月).
结果：在注册时，服用NTDs或TDs的DCM犬之间几乎没有差异;没有人的血浆或全血牛磺酸浓度低。随着时间的推移，缩短分数的改善与NTD的先前消耗显着相关，即使在对其他变量进行调整后(P=0.005)。患有DCM的狗的中位生存时间为611天（范围，NTD组的2-940天)和161天(范围，TD组12-669天）（P=.21）。猝死是两个饮食组中最常见的死亡原因。随着时间的推移，患有SCA的狗也有明显的超声心动图改善。
结论：先前食用NTDs的患有DCM或SCA的狗，然而，饮食改变后超声心动图参数显著改善。
