Abstract：
The Vimentin intermediate filament (VIF) is an essential cytoskeleton component. It shows dynamically changing expression patterns throughout various phases of the differentiation process, suggesting that the protein is physiologically important. Vimentin\'s essential functions have recently been clear, so Vimentin-deficient of animals was described as a change of morphology and signaling pathway. Recent research has discovered many vital roles for Vimentin that were previously unknown. VIF emerges as an organizer of many essential proteins involved in movement and cell signaling. The highly dynamic and complicated phosphorylation of VIF seems to be a regulator mechanism for various activities. Changes in IF expression patterns are often linked with cancer progression, especially those leading to enhanced invasion and cellular migration. This review will discuss the function of Vimentin intermediate filaments in normal cell physiology, cell adhesion structures, cell shape, and signaling pathways. The genes interaction and gene network linked with Vimentin will be discussed in more studies. However, research aimed at understanding the function of Vimentin in different signaling cascades and gene interactions might offer novel methods for creating therapeutic medicines. Enrichr GEO datasets used gene ontology (GO) and pathway enrichment analyses. STRING online was used to predict the functional connections of proteins-proteins, followed by Cytoscape analysis to find the master genes. Cytoscape and STRING research revealed that eight genes, Fas, Casp8, Casp6, Fadd, Ripk1, Des, Tnnc2, and Tnnt3, were required for protein-protein interactions with Vimentin genes involved in cell differentiation.
摘要：
波形蛋白中间丝(VIF)是必需的细胞骨架组分。它显示了在分化过程的各个阶段动态变化的表达模式，表明这种蛋白质在生理上很重要。Vimentin的基本功能最近很清楚，因此，动物的波形蛋白缺陷被描述为形态和信号通路的改变。最近的研究发现了许多以前未知的波形蛋白的重要作用。VIF是许多参与运动和细胞信号传导的必需蛋白的组织者。VIF的高度动态和复杂的磷酸化似乎是各种活动的调节机制。IF表达模式的变化通常与癌症进展有关。特别是那些导致增强的入侵和细胞迁移。本文将讨论波形蛋白中间丝在正常细胞生理中的功能。细胞粘附结构，细胞形状,和信号通路。与波形蛋白相关的基因相互作用和基因网络将在更多的研究中讨论。然而,旨在了解波形蛋白在不同信号级联和基因相互作用中的功能的研究可能为创建治疗药物提供新的方法。EnrichrGEO数据集使用基因本体论(GO)和途径富集分析。STRING在线用于预测蛋白质-蛋白质的功能连接，然后进行Cytoscape分析以找到主基因。Cytoscape和STRING研究揭示了八个基因，Fas,Casp8,Casp6,Fadd,Ripk1,Des,Tnnc2和Tnnt3是与参与细胞分化的波形蛋白基因的蛋白质-蛋白质相互作用所必需的。
