Abstract：
Rheumatoid arthritis (RA) is more common in females, and although the cause of RA is unknown, it is characterized by the production of autoantibodies. The aims of this study were to determine whether RA-associated autoantibodies are more often found in females than males and to identify factors that influence the relationship between sex and seropositivity.
Databases were searched and studies of RA (N ≥ 100) were included if they reported proportion of seropositive patients with RA by sex. Metaanalyses and metaregression were conducted using the random-effects model. Covariates regressed were smoking, age, BMI, Health Assessment Questionnaire-Disability Index (HAQ-DI), and the Disease Activity Score in 28 joints (DAS28).
Eighty-four studies with a total of 141,381 subjects with rheumatoid factor (RF) seropositivity and 95,749 subjects with anticitrullinated protein antibody (ACPA) seropositivity met inclusion criteria. The mean age of participants ranged from 37 to 68 years and the proportion of female subjects ranged from 9% to 92%. Results indicated that females were less likely than males to be seropositive: odds ratio (OR) 0.84 [95% CI 0.77-0.91] for RF and OR 0.88 [95% CI 0.81-0.95] for ACPA. BMI, smoking, mean age, DAS28, and HAQ-DI did not affect the relationship between sex and seropositivity.
Although studies report that females have higher RA disease activity than males and that seropositivity predicts worse outcomes, females were less likely to be seropositive than males.
Databases were searched and studies of RA (N ≥ 100) were included if they reported proportion of seropositive patients with RA by sex. Metaanalyses and metaregression were conducted using the random-effects model. Covariates regressed were smoking, age, BMI, Health Assessment Questionnaire-Disability Index (HAQ-DI), and the Disease Activity Score in 28 joints (DAS28).
Eighty-four studies with a total of 141,381 subjects with rheumatoid factor (RF) seropositivity and 95,749 subjects with anticitrullinated protein antibody (ACPA) seropositivity met inclusion criteria. The mean age of participants ranged from 37 to 68 years and the proportion of female subjects ranged from 9% to 92%. Results indicated that females were less likely than males to be seropositive: odds ratio (OR) 0.84 [95% CI 0.77-0.91] for RF and OR 0.88 [95% CI 0.81-0.95] for ACPA. BMI, smoking, mean age, DAS28, and HAQ-DI did not affect the relationship between sex and seropositivity.
Although studies report that females have higher RA disease activity than males and that seropositivity predicts worse outcomes, females were less likely to be seropositive than males.
摘要：
类风湿性关节炎（RA）在女性中更为常见，虽然RA的病因不明,它的特点是产生自身抗体。这项研究的目的是确定女性是否比男性更容易发现RA相关的自身抗体，并确定影响性别与血清阳性之间关系的因素。
检索数据库，并纳入RA（N≥100）的研究，如果他们报告按性别划分的RA血清阳性患者比例。使用随机效应模型进行元分析和元回归。回归的协变量是吸烟，年龄,BMI,健康评估问卷-残疾指数(HAQ-DI)，和28个关节的疾病活动评分（DAS28）。
84项研究共141,381例类风湿因子（RF）血清阳性受试者和95,749例抗瓜氨酸蛋白抗体（ACPA）血清阳性受试者符合纳入标准。参与者的平均年龄为37至68岁，女性受试者的比例为9％至92％。结果表明，与男性相比，女性血清阳性的可能性较小：RF的比值比（OR）0.84[95％CI0.77-0.91]和ACPA的OR0.88[95％CI0.81-0.95]。BMI,吸烟,平均年龄,DAS28和HAQ-DI不影响性别与血清阳性之间的关系。
尽管有研究报告说，女性的RA疾病活动度高于男性，血清阳性预示着更糟糕的结果，女性血清阳性的可能性低于男性。
检索数据库，并纳入RA（N≥100）的研究，如果他们报告按性别划分的RA血清阳性患者比例。使用随机效应模型进行元分析和元回归。回归的协变量是吸烟，年龄,BMI,健康评估问卷-残疾指数(HAQ-DI)，和28个关节的疾病活动评分（DAS28）。
84项研究共141,381例类风湿因子（RF）血清阳性受试者和95,749例抗瓜氨酸蛋白抗体（ACPA）血清阳性受试者符合纳入标准。参与者的平均年龄为37至68岁，女性受试者的比例为9％至92％。结果表明，与男性相比，女性血清阳性的可能性较小：RF的比值比（OR）0.84[95％CI0.77-0.91]和ACPA的OR0.88[95％CI0.81-0.95]。BMI,吸烟,平均年龄,DAS28和HAQ-DI不影响性别与血清阳性之间的关系。
尽管有研究报告说，女性的RA疾病活动度高于男性，血清阳性预示着更糟糕的结果，女性血清阳性的可能性低于男性。
