Abstract：
Cortical spreading depolarizations (CSDs) are characterized by waves of diminished electroencephalography activity that propagate across the cortex with subsequent loss of ionic homeostasis. CSDs have been found in many pathological conditions, including migraine, traumatic brain injury, and ischemic stroke. Because of CSD-associated ionic and metabolic disturbances at the peri-infarct area after ischemic stroke, it is thought that CSDs exacerbate tissue infarction and worsen clinical outcomes. Microglia, the main innate immune cells in the brain, are among the first responders to brain tissue damage. Recent studies demonstrated that microglia play a critical role in CSD initiation and propagation. In this article, we discuss the significance of CSD in the setting of ischemic stroke and how microglia may modulate peri-infarct CSDs, also known as iso-electric depolarizations. Finally, we discuss the significance of microglial Ca2+ and how it might be used as a potential therapeutic target for patients with ischemic stroke.
摘要：
皮质扩散去极化（CSD）的特征是脑电图活动减弱的波在整个皮质中传播，随后失去离子稳态。已经在许多病理条件下发现了CSD，包括偏头痛,创伤性脑损伤,和缺血性中风。由于CSD相关的离子和代谢紊乱在缺血性卒中后梗死周围区域，有人认为CSD会加剧组织梗死并恶化临床结局.小胶质细胞,大脑中主要的先天免疫细胞，是脑组织损伤的第一反应者之一。最近的研究表明，小胶质细胞在CSD的启动和传播中起着至关重要的作用。在这篇文章中,我们讨论了CSD在缺血性卒中的意义，以及小胶质细胞如何调节梗死周围的CSD，也称为等电去极化。最后,我们讨论了小胶质细胞Ca2+的意义,以及如何将其作为缺血性卒中患者的潜在治疗靶点.
