Abstract：
Photodermatosis is an abnormal skin inflammatory reaction to light. The major classifications of photodermatoses are idiopathic photodermatoses, photodermatoses due to exogenous or endogenous agents, photo-exacerbated dermatoses, and photosensitive genodermatoses. In this chapter, we focus on idiopathic photodermatoses and drug-related photodermatoses and emphasize on the epidemiology and immunogenetic backgrounds. Idiopathic photodermatoses, a spectrum of diseases with abnormal responses to ultraviolet radiation (UVR), include polymorphous light eruption, actinic prurigo, hydroa vacciniforme, chronic actinic dermatitis, and solar urticaria. Young people are more susceptible to most idiopathic photodermatoses except for chronic actinic dermatitis. Interestingly, idiopathic photodermatoses exhibit different characteristics between Caucasians and Asians. For example, the average age of Asian actinic prurigo patients is older than that of Caucasians in which genetic backgrounds or Fitzpatrick skin type might play a role. Drug-induced photodermatoses can be classified into phototoxic and photoallergic drug reactions. Certain drug-induced photodermatoses may mimic other dermatoses. For instance, drug-induced lupus erythematosus (LE) should be considered if an old man is diagnosed with LE but had a poor response to standard treatments.
摘要：
光性皮肤病是一种对光的异常皮肤炎症反应。光性皮肤病的主要分类是特发性光性皮肤病，由于外源性或内源性因素引起的光皮肤病，照片加剧的皮肤病，和光敏遗传病。在这一章中,我们专注于特发性光皮肤病和药物相关的光皮肤病，并强调流行病学和免疫遗传学背景。特发性光皮肤病，一系列对紫外线辐射（UVR）反应异常的疾病，包括多形光喷发，光化普鲁士,疫苗形水,慢性光化性皮炎，和太阳荨麻疹。除慢性光化性皮炎外，年轻人更容易患大多数特发性光皮肤病。有趣的是,特发性光皮肤病在白种人和亚洲人之间表现出不同的特征。例如,亚洲光化性痒疹患者的平均年龄比高加索人年龄大,其中遗传背景或Fitzpatrick皮肤类型可能起作用.药物诱导的光皮肤病可分为光毒性和光过敏性药物反应。某些药物诱导的光皮肤病可能模仿其他皮肤病。例如,如果一位老人被诊断患有红斑狼疮,但对标准治疗的反应较差,则应考虑药物诱导的红斑狼疮(LE).
