PDF(Pubmed)
Abstract：
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with unknown etiology. The pathogenesis of IBD results from immune responses to microbes in the gastrointestinal tract. Various bacterial species that are associated with human IBD have been identified. However, the microbes that trigger the development of human IBD are still not clear. Here we review bacterial species that are associated with human IBD and their pathogenic mechanisms to provide an updated broad understanding of this research field. IBD is an inflammatory syndrome rather than a single disease. We propose a three-stage pathogenesis model to illustrate the roles of different IBD-associated bacterial species and gut commensal bacteria in the development of human IBD. Finally, we recommend microbe-targeted therapeutic strategies based on the three-stage pathogenesis model.
摘要：
炎症性肠病（IBD）是一种病因不明的胃肠道慢性炎症性疾病。IBD的发病机理是对胃肠道中微生物的免疫反应。已经鉴定了与人IBD相关的各种细菌物种。然而,引发人类IBD发展的微生物仍不清楚。在这里，我们回顾了与人类IBD相关的细菌种类及其致病机制，以提供对该研究领域的最新广泛理解。IBD是一种炎症综合征，而不是单一的疾病。我们提出了一个三阶段的发病机制模型，以说明不同的IBD相关细菌种类和肠道共生细菌在人类IBD发展中的作用。最后,我们推荐基于三阶段发病机制模型的微生物靶向治疗策略.
