PDF(Pubmed)
Abstract：
UNASSIGNED: Prurigo nodularis (PN) is a chronic dermatologic condition presenting as multiple papulonodular lesions occurring with intense pruritus. Though numerous agents (topical, systemic, phototherapy and biological drugs) have been tried, the outcomes are variable.
UNASSIGNED: The aim of this study was to assess the role of topical and systemic therapies in primary PN by comparing the Pruritus Grading System (PGS) score at baseline and 1 month post-therapy.
UNASSIGNED: Of 86 diagnosed cases of PN, 49 cases of primary PN were clinically graded by Pruritus Grading System Score (PGSS), and assessed histopathologically by IHC staining (STAT-1, 3, and 6). Apart from topical agents, oral nortriptyline (mild grade), methotrexate (moderate grade) and thalidomide (severe grade) were administered, whereas doxepin was administered for itching. The PGSS was assessed after 1 month of therapy.
UNASSIGNED: Among 49 patients of PN, the majority of patients showed a significant decrease in PGSS (P = <0.001) in 1 mont, which correlated with STAT-6 expression. The combination of different topical and oral agents resulted in a statistically significant change in severity, though individual drugs did not achieve statistically significant results.
UNASSIGNED: A combination of selected oral and topical agents can effectively control the severity of PN within one month, and this was found to correlate with STAT 6 expression.
UNASSIGNED: The aim of this study was to assess the role of topical and systemic therapies in primary PN by comparing the Pruritus Grading System (PGS) score at baseline and 1 month post-therapy.
UNASSIGNED: Of 86 diagnosed cases of PN, 49 cases of primary PN were clinically graded by Pruritus Grading System Score (PGSS), and assessed histopathologically by IHC staining (STAT-1, 3, and 6). Apart from topical agents, oral nortriptyline (mild grade), methotrexate (moderate grade) and thalidomide (severe grade) were administered, whereas doxepin was administered for itching. The PGSS was assessed after 1 month of therapy.
UNASSIGNED: Among 49 patients of PN, the majority of patients showed a significant decrease in PGSS (P = <0.001) in 1 mont, which correlated with STAT-6 expression. The combination of different topical and oral agents resulted in a statistically significant change in severity, though individual drugs did not achieve statistically significant results.
UNASSIGNED: A combination of selected oral and topical agents can effectively control the severity of PN within one month, and this was found to correlate with STAT 6 expression.
摘要：
未经证实：结节性痒疹（PN）是一种慢性皮肤病，表现为多发性丘疹结节病变并伴有剧烈瘙痒。尽管众多代理商(局部，系统性，光疗和生物药物)已经尝试过，结果是可变的。
UNASSIGNED：本研究的目的是通过比较基线和治疗后1个月的瘙痒评分系统（PGS）评分来评估局部和全身治疗在原发性PN中的作用。
未经证实：在86例确诊的PN病例中，49例原发性PN采用瘙痒评分系统评分(PGSS)进行临床分级,并通过IHC染色(STAT-1、3和6)进行组织病理学评估。除了外用药物,口服去甲替林（轻度），给予甲氨蝶呤（中度）和沙利度胺（重度），而多塞平用于瘙痒。治疗1个月后评估PGSS。
未经证实：在49例PN患者中，大多数患者在1个月内PGSS显着下降（P=<0.001），与STAT-6表达相关。不同的局部和口服药物的组合导致严重程度的统计学显着变化，尽管个别药物没有达到统计学上显著的结果。
UNASSIGNED：选定的口服和外用药物的组合可在一个月内有效控制PN的严重程度，发现这与STAT6表达相关。
UNASSIGNED：本研究的目的是通过比较基线和治疗后1个月的瘙痒评分系统（PGS）评分来评估局部和全身治疗在原发性PN中的作用。
未经证实：在86例确诊的PN病例中，49例原发性PN采用瘙痒评分系统评分(PGSS)进行临床分级,并通过IHC染色(STAT-1、3和6)进行组织病理学评估。除了外用药物,口服去甲替林（轻度），给予甲氨蝶呤（中度）和沙利度胺（重度），而多塞平用于瘙痒。治疗1个月后评估PGSS。
未经证实：在49例PN患者中，大多数患者在1个月内PGSS显着下降（P=<0.001），与STAT-6表达相关。不同的局部和口服药物的组合导致严重程度的统计学显着变化，尽管个别药物没有达到统计学上显著的结果。
UNASSIGNED：选定的口服和外用药物的组合可在一个月内有效控制PN的严重程度，发现这与STAT6表达相关。
