UNASSIGNED: Prospective, randomized, double-blind design was followed. One hundred and two American Society of Anesthesiologists I to III patients undergoing unilateral TKR surgeries were included in the study and randomized into two groups. Group C received Clonidine 150 mcg and Group D received Dexmedetomidine 100 mcg as an add on to 30 mL of 0.2% ropivacaine for adductor canal block. Postoperatively, duration of analgesia, sedation score, rescue analgesic requirement, hemodynamics, and any other adverse effects were monitored.
UNASSIGNED: The total duration of analgesia in Group D (16.01 h [standard deviation [S. D]-0.5]) was significantly higher as compared to Group C (13.02 h [S. D-0.5]) (P < 0.0001). The numerical rating score (NRS) was significantly lower in Group D compared to Group C (P < 0.05) at multiple postoperative timelines. Group D (2.25(S. D-0.44)) had better sedation scores as compared to Group C (2 [S. D-0]) (P = 0.001).
UNASSIGNED: Dexmedetomidine has longer duration, lower pain, and better sedation scores as compared to clonidine in adductor canal blocks for postoperative pain relief in TKR surgeries.
未经批准:预期,随机化,遵循双盲设计。研究中包括了一百零二名美国麻醉医师协会I至III接受单侧TKR手术的患者,并将其随机分为两组。C组接受可乐定150mcg,D组接受右美托咪定100mcg作为30mL0.2%罗哌卡因用于内收肌管阻滞。术后,镇痛持续时间,镇静评分,抢救镇痛需求,血流动力学,并监测任何其他不良反应.
未经证实:D组镇痛的总持续时间(16.01h[标准偏差[S.D]-0.5])显著高于C组(13.02h[S.D-0.5])(P<0.0001)。在多个术后时间线,D组的数值评分(NRS)明显低于C组(P<0.05)。D组(2.25(S.D-0.44))的镇静评分优于C组(2[S.D-0])(P=0.001)。
UNASSIGNED:右美托咪定持续时间较长,降低疼痛,与可乐定相比,内收肌管阻滞的镇静评分更好,可缓解TKR手术的术后疼痛。