PDF(Pubmed)
Abstract：
UNASSIGNED: Total knee replacement (TKR) surgeries are associated with significant postoperative pain. Ultrasound-guided adductor canal block is associated with better pain scores. The addition of Clonidine and Dexmedetomidine as additives to local anesthetics was the recent focus of interest. However, there are minimal studies comparing the duration of analgesia as additives to Ropivacaine in ultrasound-guided adductor canal block for TKRs.
UNASSIGNED: Prospective, randomized, double-blind design was followed. One hundred and two American Society of Anesthesiologists I to III patients undergoing unilateral TKR surgeries were included in the study and randomized into two groups. Group C received Clonidine 150 mcg and Group D received Dexmedetomidine 100 mcg as an add on to 30 mL of 0.2% ropivacaine for adductor canal block. Postoperatively, duration of analgesia, sedation score, rescue analgesic requirement, hemodynamics, and any other adverse effects were monitored.
UNASSIGNED: The total duration of analgesia in Group D (16.01 h [standard deviation [S. D]-0.5]) was significantly higher as compared to Group C (13.02 h [S. D-0.5]) (P < 0.0001). The numerical rating score (NRS) was significantly lower in Group D compared to Group C (P < 0.05) at multiple postoperative timelines. Group D (2.25(S. D-0.44)) had better sedation scores as compared to Group C (2 [S. D-0]) (P = 0.001).
UNASSIGNED: Dexmedetomidine has longer duration, lower pain, and better sedation scores as compared to clonidine in adductor canal blocks for postoperative pain relief in TKR surgeries.
UNASSIGNED: Prospective, randomized, double-blind design was followed. One hundred and two American Society of Anesthesiologists I to III patients undergoing unilateral TKR surgeries were included in the study and randomized into two groups. Group C received Clonidine 150 mcg and Group D received Dexmedetomidine 100 mcg as an add on to 30 mL of 0.2% ropivacaine for adductor canal block. Postoperatively, duration of analgesia, sedation score, rescue analgesic requirement, hemodynamics, and any other adverse effects were monitored.
UNASSIGNED: The total duration of analgesia in Group D (16.01 h [standard deviation [S. D]-0.5]) was significantly higher as compared to Group C (13.02 h [S. D-0.5]) (P < 0.0001). The numerical rating score (NRS) was significantly lower in Group D compared to Group C (P < 0.05) at multiple postoperative timelines. Group D (2.25(S. D-0.44)) had better sedation scores as compared to Group C (2 [S. D-0]) (P = 0.001).
UNASSIGNED: Dexmedetomidine has longer duration, lower pain, and better sedation scores as compared to clonidine in adductor canal blocks for postoperative pain relief in TKR surgeries.
摘要：
未经授权：全膝关节置换（TKR）手术与术后明显疼痛相关。超声引导内收肌管阻滞与更好的疼痛评分相关。在局部麻醉药中加入可乐定和右美托咪定作为添加剂是最近关注的焦点。然而,很少有研究比较罗哌卡因添加剂在超声引导下TKRs内收肌管阻滞中镇痛的持续时间。
未经批准：预期，随机化，遵循双盲设计。研究中包括了一百零二名美国麻醉医师协会I至III接受单侧TKR手术的患者，并将其随机分为两组。C组接受可乐定150mcg，D组接受右美托咪定100mcg作为30mL0.2％罗哌卡因用于内收肌管阻滞。术后,镇痛持续时间，镇静评分,抢救镇痛需求，血流动力学,并监测任何其他不良反应.
未经证实：D组镇痛的总持续时间（16.01h[标准偏差[S.D]-0.5])显著高于C组(13.02h[S.D-0.5])(P<0.0001)。在多个术后时间线，D组的数值评分（NRS）明显低于C组（P<0.05）。D组(2.25(S.D-0.44))的镇静评分优于C组(2[S.D-0])(P=0.001)。
UNASSIGNED：右美托咪定持续时间较长，降低疼痛，与可乐定相比，内收肌管阻滞的镇静评分更好，可缓解TKR手术的术后疼痛。
未经批准：预期，随机化，遵循双盲设计。研究中包括了一百零二名美国麻醉医师协会I至III接受单侧TKR手术的患者，并将其随机分为两组。C组接受可乐定150mcg，D组接受右美托咪定100mcg作为30mL0.2％罗哌卡因用于内收肌管阻滞。术后,镇痛持续时间，镇静评分,抢救镇痛需求，血流动力学,并监测任何其他不良反应.
未经证实：D组镇痛的总持续时间（16.01h[标准偏差[S.D]-0.5])显著高于C组(13.02h[S.D-0.5])(P<0.0001)。在多个术后时间线，D组的数值评分（NRS）明显低于C组（P<0.05）。D组(2.25(S.D-0.44))的镇静评分优于C组(2[S.D-0])(P=0.001)。
UNASSIGNED：右美托咪定持续时间较长，降低疼痛，与可乐定相比，内收肌管阻滞的镇静评分更好，可缓解TKR手术的术后疼痛。
