PDF(Pubmed)
Abstract：
Skin-resident stromal cells, including keratinocytes, fibroblasts, adipocytes, and immune cells including Langerhans cells, dendritic cells, T cells, and innate lymphoid cells, and their functional products work in concert to ensure the realization of skin barrier immunity. However, aging-induced immunosenescence predisposes the elderly to pruritic dermatoses, including type 2 inflammation-mediated. Inflammaging, characterized by chronic low level of pro-inflammatory cytokines released from senescent cells with the senescence-associated secretory phenotype (SASP), may drive immunosenescence and tangle with type 2 inflammatory dermatoses. The present mini-review summarizes current evidence on immunosenescence and type 2 inflammation in the skin and further focuses on future needs from an inflammaging perspective to clarify their complexity.
摘要：
皮肤常驻基质细胞，包括角质形成细胞,成纤维细胞,脂肪细胞,免疫细胞包括朗格汉斯细胞，树突状细胞,T细胞,和先天的淋巴样细胞，和他们的功能产品协同工作，以确保皮肤屏障免疫的实现。然而,衰老诱导的免疫衰老使老年人容易患上瘙痒性皮肤病，包括2型炎症介导的。发炎，以衰老相关分泌表型（SASP）的衰老细胞释放的促炎细胞因子的慢性低水平为特征，可能导致免疫衰老并与2型炎症性皮肤病缠结。本小型综述总结了当前有关皮肤免疫衰老和2型炎症的证据，并从炎症的角度进一步关注未来的需求，以阐明其复杂性。
