Abstract:
The amygdala is mainly known for its role in the pathogenesis of anxiety and the initiation of fear responses. However, there is growing evidence showing that the amygdala\'s ability to respond to internal stimuli such as CO2 is limited, thereby challenging its role in the brain-behavior relationship. Based on these results and the strong inhibitory connections between the central nucleus of the amygdala and key brainstem areas regulating the reflexive respiratory responses to CO2, Feinstein et al. propose amygdala-driven apnea as a novel mechanism in the chemoreceptive origin of anxiety.
摘要:
杏仁核主要因其在焦虑的发病机理和恐惧反应的启动中的作用而闻名。然而,越来越多的证据表明杏仁核对CO2等内部刺激的反应能力有限,从而挑战其在大脑行为关系中的作用。根据这些结果以及杏仁核中央核与调节对CO2的反射性呼吸反应的关键脑干区域之间的强抑制联系,Feinstein等人。提出杏仁核驱动的呼吸暂停作为焦虑的化学接受起源的新机制。