Abstract：
BACKGROUND: The aim of this study was to investigate the long-term visual outcomes and factors associated with vision loss in Chinese patients with primary congenital glaucoma (PCG) after successful intraocular pressure (IOP) control (IOP ≤21 mm Hg).
METHODS: PCG patients with IOP control who were examined in the glaucoma clinic at Zhongshan Ophthalmic Center from 2019 to 2020 were enrolled. The final visual outcome was evaluated by the best corrected visual acuity (VA). Univariate and multivariate analyses were used to investigate the associations of visual impairment with potential risk factors. The causes for decreased VA (<20/50) were also analyzed.
RESULTS: Fifty-nine patients (95 eyes) were included in the cohort, with a mean age of 8.7 years. The mean logMAR VA was 0.62 ± 0.64. The VAs of eyes treated for PCG were good (≥20/50) in 56%, fair (20/60-20/200) in 30%, and poor (<20/200) in 14%. The most common cause of decreased VA was amblyopia (64.3%). Multivariate logistic regression analysis showed that undergoing multiple surgeries (OR: 4.86, 95% CI: 1.11-21.16, p = 0.035) was significantly associated with visual impairment.
CONCLUSIONS: The results showed that good VA was attainable in approximately half of PCG eyes under IOP control. Prompt and effective treatment of PCG, management of amblyopia and ocular comorbidities may be potential steps toward achieving good visual outcomes in PCG patients.
METHODS: PCG patients with IOP control who were examined in the glaucoma clinic at Zhongshan Ophthalmic Center from 2019 to 2020 were enrolled. The final visual outcome was evaluated by the best corrected visual acuity (VA). Univariate and multivariate analyses were used to investigate the associations of visual impairment with potential risk factors. The causes for decreased VA (<20/50) were also analyzed.
RESULTS: Fifty-nine patients (95 eyes) were included in the cohort, with a mean age of 8.7 years. The mean logMAR VA was 0.62 ± 0.64. The VAs of eyes treated for PCG were good (≥20/50) in 56%, fair (20/60-20/200) in 30%, and poor (<20/200) in 14%. The most common cause of decreased VA was amblyopia (64.3%). Multivariate logistic regression analysis showed that undergoing multiple surgeries (OR: 4.86, 95% CI: 1.11-21.16, p = 0.035) was significantly associated with visual impairment.
CONCLUSIONS: The results showed that good VA was attainable in approximately half of PCG eyes under IOP control. Prompt and effective treatment of PCG, management of amblyopia and ocular comorbidities may be potential steps toward achieving good visual outcomes in PCG patients.
摘要：
背景：本研究的目的是调查成功控制眼压（IOP）（IOP≤21mmHg）后中国原发性先天性青光眼（PCG）患者的长期视力结果和与视力丧失相关的因素。
方法：选择2019-2020年在中山眼科中心青光眼门诊检查的眼压控制下的PCG患者。通过最佳矫正视力（VA）评估最终视力结果。使用单变量和多变量分析来调查视力损害与潜在危险因素的关联。还分析了VA降低(<20/50)的原因。
结果：59例患者（95只眼）被纳入队列，平均年龄8.7岁.平均logMARVA为0.62±0.64。接受PCG治疗的眼睛的VAs良好（≥20/50），占56％，公平(20/60-20/200)在30%，差（<20/200）14%。VA降低的最常见原因是弱视（64.3％）。多因素logistic回归分析显示,多次手术(OR:4.86,95%CI:1.11~21.16,p=0.035)与视力障碍显著相关。
结论：结果表明，在IOP控制下，大约一半的PCG眼中可以获得良好的VA。及时有效的治疗PCG，治疗弱视和眼部合并症可能是PCG患者取得良好视力结局的潜在步骤.
方法：选择2019-2020年在中山眼科中心青光眼门诊检查的眼压控制下的PCG患者。通过最佳矫正视力（VA）评估最终视力结果。使用单变量和多变量分析来调查视力损害与潜在危险因素的关联。还分析了VA降低(<20/50)的原因。
结果：59例患者（95只眼）被纳入队列，平均年龄8.7岁.平均logMARVA为0.62±0.64。接受PCG治疗的眼睛的VAs良好（≥20/50），占56％，公平(20/60-20/200)在30%，差（<20/200）14%。VA降低的最常见原因是弱视（64.3％）。多因素logistic回归分析显示,多次手术(OR:4.86,95%CI:1.11~21.16,p=0.035)与视力障碍显著相关。
结论：结果表明，在IOP控制下，大约一半的PCG眼中可以获得良好的VA。及时有效的治疗PCG，治疗弱视和眼部合并症可能是PCG患者取得良好视力结局的潜在步骤.
