A novel HLA-A null allele, HLA-A*31:188N, identified by next-generation sequencing in a Chinese individual.

一个新的 HLA - A 无效等位基因,HLA - A * 31: 188N,通过中国个体的下一代测序鉴定。

• 影响指数: 8.762
• 发表时间: 07 2022
• 来源期刊: HLA
• DOI: 10.1111/tan.14596
• PMID: 35263510
• 文章类型: Case Reports
• 中科院分区: Q4
• 方向: 医学
• 作者列表: Gao SQ

关键词: HLA; next-generation sequencing; null allele

Mesh: Alleles; Asians / genetics; China; HLA-A Antigens / genetics; High-Throughput Nucleotide Sequencing; Humans

Abstract

The HLA-A*31:188N allele differs from A*31:01:02:01 by a single nucleotide deletion in exon 3.

摘要

HLA-A*31:188N等位基因与A*31:01:02:01的不同之处在于外显子3中的单核苷酸缺失。