PDF(Pubmed)
Abstract：
The Hippo-YAP pathway is fast becoming a key instrument in regulating cancers. Binary oppositions, also known as the Yin-Yang dynamics in Chinese, have emerged in its effects. Some oppositions are attributable to in vitro and in vivo experimental conditions, some are due to differences between cancers or species, some are derived from its inherent duality endowed by upstream and downstream signaling, and some are yet unresolved mysteries. However, as bewildering they are, few have been noticed and defined so far. In this review, we first look back on the Hippo pathway which was initially identified more than a decade ago. We then focus on tumor biology, especially some latest popular mechanisms that regulate tumor cell survival, such as ferroptosis, autophagy, and apoptosis. The third chapter is concerned with the findings of the relationship between the Hippo pathway and tumor immunity on the microenvironment in which tumor cells progress. In each of these main sections the contradictory points of the Hippo pathway are elucidated and thoroughly examined. On one hand, the Yin-Yang dynamics of the Hippo pathway brings about considerable challenges for current research; on the other hand, this work will generate fresh insight into it and offer opportunities for subsequent drug development for cancer and regenerative medicine.
摘要：
Hippo-YAP途径正迅速成为调节癌症的关键工具。二元对立,在汉语中也被称为阴阳动力学，已经出现了它的影响。一些反对归因于体外和体内实验条件，有些是由于癌症或物种之间的差异，有些是由上游和下游信令赋予的固有二重性得出的，还有一些尚未解开的谜团。然而,令人困惑的他们，到目前为止，很少有人注意到和定义。在这次审查中,我们首先回顾了十多年前最初发现的河马途径。然后我们专注于肿瘤生物学，尤其是一些最新流行的调节肿瘤细胞存活的机制，比如铁中毒，自噬,和凋亡。第三章是关于Hippo通路与肿瘤免疫在肿瘤细胞发展的微环境中的关系的发现。在这些主要部分的每一个中，都阐明了河马途径的矛盾点并进行了彻底检查。一方面,河马途径的阴阳动力学给当前的研究带来了相当大的挑战;另一方面,这项工作将对其产生新的见解，并为随后的癌症和再生医学药物开发提供机会。
