RAMPs 对胰高血糖素受体家族信号通路的调节作用.
关键词: AMY, amylin Allosteric modulation BRET, bioluminescence resonance energy transfer Bmax, maximum measured BRET value CGRP, calcitonin gene-related peptide CLR, calcitonin-like receptor EC50, half maximal effective concentration ECD, extracellular domain Emax, maximal response G protein-coupled receptor GCGR, glucagon receptor GHRHR, hormone-releasing hormone receptor GIPR, gastric inhibitory polypeptide receptor or glucose-dependent insulinotropic polypeptide GLP-1R, glucagon-like peptide-1 receptor GLP-2R, glucagon-like peptide-2 receptor GPCRs, G protein-coupled receptors GPCR–RAMP interaction Glucagon receptor family Ligand selectivity RAMP, receptor activity-modulating protein Receptor activity-modulating protein Receptor pharmacology Rluc, Renilla luciferase SBA, suspension bead array SCTR, secretin receptor SV, splice variant Signaling TMD, transmembrane domain VPAC2R, vasoactive intestinal polypeptide 2 receptor cAMP, cyclic adenosine monophosphate pEC50, negative logarithm of EC50 β2-AR, β2-adrenergic receptor AMY, amylin Allosteric modulation BRET, bioluminescence resonance energy transfer Bmax, maximum measured BRET value CGRP, calcitonin gene-related peptide CLR, calcitonin-like receptor EC50, half maximal effective concentration ECD, extracellular domain Emax, maximal response G protein-coupled receptor GCGR, glucagon receptor GHRHR, hormone-releasing hormone receptor GIPR, gastric inhibitory polypeptide receptor or glucose-dependent insulinotropic polypeptide GLP-1R, glucagon-like peptide-1 receptor GLP-2R, glucagon-like peptide-2 receptor GPCRs, G protein-coupled receptors GPCR–RAMP interaction Glucagon receptor family Ligand selectivity RAMP, receptor activity-modulating protein Receptor activity-modulating protein Receptor pharmacology Rluc, Renilla luciferase SBA, suspension bead array SCTR, secretin receptor SV, splice variant Signaling TMD, transmembrane domain VPAC2R, vasoactive intestinal polypeptide 2 receptor cAMP, cyclic adenosine monophosphate pEC50, negative logarithm of EC50 β2-AR, β2-adrenergic receptor
来 源:
DOI:10.1016/j.apsb.2021.07.028
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