Abstract：
OBJECTIVE: Obesity is prevalent and has a negative impact on women\'s health, including sexual dysfunction. Recent review articles suggest improvement in Female Sexual Function Index (FSFI) and proportion of female sexual dysfunction (FSD) among women with obesity after bariatric surgery.
METHODS: We pooled data from 16 observational studies involving 953 women. The study outcomes were mean FSFI scores and proportion of FSD before and after bariatric surgery. We also sub-analyzed whether age and duration of follow-up affected these outcomes.
RESULTS: The mean age of the subjects was 39.4 ± 4.2 years. Body mass index (BMI) showed significant reduction postoperatively (p < 0.0001). Bariatric surgery led to significant improvement in total FSFI score (p = 0.0005), and all sexual domains except pain. Bariatric surgery reduced the odds of having FSD by 76% compared with those who did not undergo operation (OR 0.24, 95% CI = 0.17, 0.33, p < 0.0001). Our sub-analysis demonstrated a significant reduction in the proportion of FSD for patients <40 years of age. The improvement of total FSFI scores and reduction in proportion of FSD remained significant within the first 12 months after surgery. Univariate meta-regression showed that BMI was not a significant covariate for improvement of FSFI scores (β = 0.395, p = 0.1, 95% CI = 0.884, 0.095).
CONCLUSIONS: Bariatric surgery is shown to improve sexual function scores and prevalence of FSD. This is especially significant among women <40 years of age. This benefit remained significant within the first year after surgery. This appears to be an additional benefit for these patients.
METHODS: We pooled data from 16 observational studies involving 953 women. The study outcomes were mean FSFI scores and proportion of FSD before and after bariatric surgery. We also sub-analyzed whether age and duration of follow-up affected these outcomes.
RESULTS: The mean age of the subjects was 39.4 ± 4.2 years. Body mass index (BMI) showed significant reduction postoperatively (p < 0.0001). Bariatric surgery led to significant improvement in total FSFI score (p = 0.0005), and all sexual domains except pain. Bariatric surgery reduced the odds of having FSD by 76% compared with those who did not undergo operation (OR 0.24, 95% CI = 0.17, 0.33, p < 0.0001). Our sub-analysis demonstrated a significant reduction in the proportion of FSD for patients <40 years of age. The improvement of total FSFI scores and reduction in proportion of FSD remained significant within the first 12 months after surgery. Univariate meta-regression showed that BMI was not a significant covariate for improvement of FSFI scores (β = 0.395, p = 0.1, 95% CI = 0.884, 0.095).
CONCLUSIONS: Bariatric surgery is shown to improve sexual function scores and prevalence of FSD. This is especially significant among women <40 years of age. This benefit remained significant within the first year after surgery. This appears to be an additional benefit for these patients.
摘要：
目的：肥胖普遍存在，对女性健康有负面影响，包括性功能障碍.最近的评论文章表明，减肥手术后肥胖女性中女性性功能指数（FSFI）和女性性功能障碍（FSD）的比例有所改善。
方法：我们汇集了16项观察性研究的数据，涉及953名女性。研究结果是减重手术前后的平均FSFI评分和FSD比例。我们还分析了年龄和随访时间是否影响这些结果。
结果：受试者的平均年龄为39.4±4.2岁。术后体重指数(BMI)显著降低(p<0.0001)。减肥手术导致FSFI总评分显著改善（p=0.0005），和所有的性领域，除了疼痛。与未接受手术的患者相比，减重手术将FSD的几率降低了76％（OR0.24，95％CI=0.17，0.33，p<0.0001）。我们的子分析表明，年龄<40岁的患者的FSD比例显着降低。在手术后的前12个月内，FSFI总分的改善和FSD比例的降低仍然显着。单因素meta回归显示BMI不是FSFI评分改善的显著协变量(β=0.395,p=0.1,95%CI=0.884,0.095)。
结论：减重手术可改善性功能评分和FSD患病率。这在40岁以下的女性中尤其重要。这种益处在手术后的第一年内仍然显著。这似乎是对这些患者的额外益处。
方法：我们汇集了16项观察性研究的数据，涉及953名女性。研究结果是减重手术前后的平均FSFI评分和FSD比例。我们还分析了年龄和随访时间是否影响这些结果。
结果：受试者的平均年龄为39.4±4.2岁。术后体重指数(BMI)显著降低(p<0.0001)。减肥手术导致FSFI总评分显著改善（p=0.0005），和所有的性领域，除了疼痛。与未接受手术的患者相比，减重手术将FSD的几率降低了76％（OR0.24，95％CI=0.17，0.33，p<0.0001）。我们的子分析表明，年龄<40岁的患者的FSD比例显着降低。在手术后的前12个月内，FSFI总分的改善和FSD比例的降低仍然显着。单因素meta回归显示BMI不是FSFI评分改善的显著协变量(β=0.395,p=0.1,95%CI=0.884,0.095)。
结论：减重手术可改善性功能评分和FSD患病率。这在40岁以下的女性中尤其重要。这种益处在手术后的第一年内仍然显著。这似乎是对这些患者的额外益处。
