Abstract:
In this study, we report a case of a late-stage clival chordoma in a 29-year-old African American male and the unfortunate linear progression course since his initial diagnosis. Upon his initial encounter in 2020, radiation therapy did not offer any promising curative outcome. He was initially treated with a combination treatment of partial resection, radiation, and proposed oral imatinib, none of which modified the natural history and progression of his illness. Instead, these methods were performed as palliative measures to reduce the current size of the tumors and decrease growth rates to minimize his pain. Social issues acted as a contributory risk factor in his prognosis and due to the patient\'s socioeconomic barriers, he was not able to continue seeking available radiotherapy, leading to disease exacerbation. Poor adherence was noted with his follow-up. The risks of being affected by this disease are likely multifactorial and more reports of such cases need to be added to bridge this gap in the current literature. In addition, there is a gap in the current study of reports of such tumors found in diverse racial groups and in patients who are in their first few decades of life. Novel treatment strategies were reviewed, and it is expected they could generate assertive treatment guidelines.
摘要:
在这项研究中,我们报道了一例29岁非裔美国男性的晚期斜坡脊索瘤病例,该病例自初次诊断以来出现了不幸的线性进展过程.在他于2020年初次接触时,放射治疗并没有提供任何有希望的治疗结果。他最初接受了部分切除的联合治疗,辐射,并建议口服伊马替尼,这些都没有改变他疾病的自然史和进展。相反,这些方法作为姑息措施进行,以减少肿瘤的当前大小和降低生长速率,从而最大限度地减少他的疼痛.由于患者的社会经济障碍,社会问题在他的预后中起着重要的作用,他无法继续寻求可用的放射治疗,导致疾病恶化。他的后续行动注意到依从性差。受这种疾病影响的风险可能是多因素的,需要增加更多此类病例的报告来弥合目前文献中的这一差距。此外,目前对在不同种族群体和生命最初几十年的患者中发现的此类肿瘤的报告的研究存在差距。回顾了新的治疗策略,预计他们可以产生自信的治疗指南。