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Abstract：
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has created an immense menace to public health worldwide, exerting huge effects on global economic and political conditions. Understanding the biology and pathogenesis mechanisms of this novel virus, in large parts, relies on optimal physiological models that allow replication and propagation of SARS-CoV-2. Human organoids, derived from stem cells, are three-dimensional cell cultures that recapitulate the cellular organization, transcriptional and epigenetic signatures of their counterpart organs. Recent studies have indicated their great values as experimental virology platforms, making human organoid an ideal tool for investigating host-pathogen interactions. Here, we summarize research developments for SARS-CoV-2 infection of various human organoids involved in multiple systems, including lung, liver, brain, intestine, kidney and blood vessel organoids. These studies help us reveal the pathogenesis mechanism of COVID-19, and facilitate the development of effective vaccines and drugs as well as other therapeutic regimes.
摘要：
2019年冠状病毒病（COVID-19），由严重急性呼吸综合征冠状病毒-2（SARS-CoV-2）引起，对全世界的公共卫生造成了巨大的威胁，对全球经济和政治状况产生巨大影响。了解这种新型病毒的生物学和发病机制，在很大的部分，依赖于允许SARS-CoV-2复制和传播的最佳生理模型。人类类器官，来源于干细胞，是概括细胞组织的三维细胞培养物，其对应器官的转录和表观遗传特征。最近的研究表明它们作为实验病毒学平台的巨大价值，使人类类器官成为研究宿主-病原体相互作用的理想工具。这里,我们总结了SARS-CoV-2感染涉及多个系统的各种人类类器官的研究进展，包括肺,肝脏,大脑,肠,肾脏和血管类器官。这些研究有助于我们揭示COVID-19的发病机制，并促进有效疫苗和药物以及其他治疗方案的开发。
