PDF(Pubmed)
Abstract：
COVID-19 infection was mainly associated with respiratory symptoms, but lately, ischemic stroke (IS) has been reported in several cases. The incidence of IS in SARS-CoV-2 infection is increasing, and its mechanism is still not fully understood. Calcitonin gene-related peptide (CGRP) -the abundantly expressed protein in the peripheral and central nervous system- showed low expression in SARS-CoV-2 patients. This peptide is strongly implicated in regulating cerebral blood flow (CBF) and improving neurological deficits after cerebral arterial occlusion. We assume that a possible interplay between the low circulating levels of CGRP may affect CBF, thus worsening the symptoms of IS in SARS-CoV-2 patients.
摘要：
COVID-19感染主要与呼吸道症状有关，但最近,缺血性卒中（IS）已在一些病例中报告。SARS-CoV-2感染中IS的发病率正在增加，其机制仍未完全理解。降钙素基因相关肽（CGRP）-在外周和中枢神经系统中大量表达的蛋白质-在SARS-CoV-2患者中呈低表达。该肽与调节脑血流量（CBF）和改善脑动脉闭塞后的神经功能缺损密切相关。我们假设CGRP的低循环水平之间可能的相互作用可能会影响CBF，从而加重SARS-CoV-2患者的IS症状。
