关键词: Astronauts Cortical tissue freezing Fertility preservation GCR Infertility Mars mission Menopause Ovarian reserve Premature ovarian failure Primordial follicles Radiation hazard Space program Space radiation

Mesh : Astronauts Cryopreservation Female Humans Menopause Ovarian Follicle Ovarian Reserve Space Flight

来  源:   DOI:10.1016/j.ejogrb.2022.02.022

Abstract:
Space travel has different effects on the reproductive capacity of women compared to men. The radiation exposure intrinsic to deep space travel causes destruction of some of a woman\'s primordial follicles. Data suggests that a typical Mars mission may reduce a women\'s ovarian reserve by about 50%. This has consequences to a woman\'s reproductive capacity and, more significantly, decreases the time interval to her menopause. A reduced time interval to menopause is associated with earlier mortality. Estrogen replacement therapy and cryopreservation of a female astronaut\'s oocytes may be used to address these issues. However, cortical tissue freezing provides advantages to more directly compensate for these workplace complications. Cortical tissue freezing especially provides advantages if there are plans to reproduce in an extraterrestrial location.
摘要:
与男性相比,太空旅行对女性生殖能力的影响不同。深空旅行固有的辐射暴露会破坏一些女性的原始卵泡。数据表明,典型的火星任务可能会使女性的卵巢储备减少约50%。这对女人的生殖能力有影响,更重要的是,减少她更年期的时间间隔。绝经时间间隔缩短与早期死亡率相关。雌激素替代疗法和女性宇航员卵母细胞的冷冻保存可用于解决这些问题。然而,皮质组织冷冻提供了更直接补偿这些工作场所并发症的优势.如果有计划在外星位置繁殖,则皮质组织冷冻尤其提供优势。
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