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Abstract：
BACKGROUND: Psoriasis (PsO), a chronic inflammatory, multisystemic, and multifactorial disease can cause endothelial dysfunction, artery calcification, and atherosclerotic disease. A higher incidence of vascular occlusive events has been observed in psoriatic patients compared to healthy controls, and multiple studies confirm the association between moderate-severe PsO and atherosclerosis, coronary artery calcification, and higher cardiovascular risk.
OBJECTIVE: We sought to analyze atherosclerotic disease prevalence in epiaortic vessels of psoriatic and non-psoriatic patients to understand if PsO could represent an independent risk factor predisposing to atherosclerotic disease.
METHODS: We evaluated 47 psoriatic patients without cardiovascular risk factors with color Doppler ultrasound (CDUS). If atheromatous plaques were detected, a computed tomography angiography (CTA) was performed. We evaluated 47 non-psoriatic patients without cardiovascular risk factors with CDUS. Atherosclerosis prevalence in both groups were statistically analyzed. CDUS performance was compared to CTA.
RESULTS: In the psoriatic group (mean age 50.9 years), 6 had atheromatous plaques and 12 had an intima-media thickness (IMT) > 1 mm (overall prevalence of atherosclerotic disease: 38.2%). All plaques detected with CDUS were confirmed at CTA. In the control group (mean age 51.3 years), CDUS revealed atheromatous plaques in 4 patients and IMT > 1 mm in 4 ones (overall prevalence of 17%). The difference of atherosclerotic disease prevalence between the groups was statistically significant (P < 0.05).
CONCLUSIONS: Our results highlight that PsO could be considered a predisposing factor for atherosclerotic disease development in epiaortic vessels, as it causes an increased IMT, that is also considered an independent cardiovascular risk factor.
OBJECTIVE: We sought to analyze atherosclerotic disease prevalence in epiaortic vessels of psoriatic and non-psoriatic patients to understand if PsO could represent an independent risk factor predisposing to atherosclerotic disease.
METHODS: We evaluated 47 psoriatic patients without cardiovascular risk factors with color Doppler ultrasound (CDUS). If atheromatous plaques were detected, a computed tomography angiography (CTA) was performed. We evaluated 47 non-psoriatic patients without cardiovascular risk factors with CDUS. Atherosclerosis prevalence in both groups were statistically analyzed. CDUS performance was compared to CTA.
RESULTS: In the psoriatic group (mean age 50.9 years), 6 had atheromatous plaques and 12 had an intima-media thickness (IMT) > 1 mm (overall prevalence of atherosclerotic disease: 38.2%). All plaques detected with CDUS were confirmed at CTA. In the control group (mean age 51.3 years), CDUS revealed atheromatous plaques in 4 patients and IMT > 1 mm in 4 ones (overall prevalence of 17%). The difference of atherosclerotic disease prevalence between the groups was statistically significant (P < 0.05).
CONCLUSIONS: Our results highlight that PsO could be considered a predisposing factor for atherosclerotic disease development in epiaortic vessels, as it causes an increased IMT, that is also considered an independent cardiovascular risk factor.
摘要：
背景：银屑病（PsO），慢性炎症，多系统，多因素疾病会导致内皮功能障碍，动脉钙化,和动脉粥样硬化疾病。与健康对照组相比，银屑病患者血管闭塞事件的发生率更高。多项研究证实了中重度PsO与动脉粥样硬化之间的关系，冠状动脉钙化,和更高的心血管风险。
目的：我们试图分析银屑病患者和非银屑病患者的上主动脉血管动脉粥样硬化性疾病患病率，以了解PsO是否可能是诱发动脉粥样硬化性疾病的独立危险因素。
方法：我们用彩色多普勒超声（CDUS）评估了47例无心血管危险因素的银屑病患者。如果检测到动脉粥样斑块，进行了计算机断层扫描血管造影(CTA).我们用CDUS评估了47例无心血管危险因素的非银屑病患者。对两组动脉粥样硬化患病率进行统计学分析。将CDUS性能与CTA进行比较。
结果：在银屑病组（平均年龄50.9岁），6例具有动脉粥样硬化斑块,12例具有内膜-中膜厚度(IMT)>1mm(动脉粥样硬化疾病的总体患病率:38.2%)。用CDUS检测的所有斑块均在CTA确认。对照组（平均年龄51.3岁），CDUS显示4例患者动脉粥样硬化斑块，4例患者IMT>1mm（总患病率为17％）。各组间动脉粥样硬化性疾病患病率差异有统计学意义(P<0.05)。
结论：我们的研究结果强调，PsO可能被认为是上主动脉血管动脉粥样硬化疾病发展的诱发因素，因为它会导致IMT增加，这也被认为是一个独立的心血管危险因素。
目的：我们试图分析银屑病患者和非银屑病患者的上主动脉血管动脉粥样硬化性疾病患病率，以了解PsO是否可能是诱发动脉粥样硬化性疾病的独立危险因素。
方法：我们用彩色多普勒超声（CDUS）评估了47例无心血管危险因素的银屑病患者。如果检测到动脉粥样斑块，进行了计算机断层扫描血管造影(CTA).我们用CDUS评估了47例无心血管危险因素的非银屑病患者。对两组动脉粥样硬化患病率进行统计学分析。将CDUS性能与CTA进行比较。
结果：在银屑病组（平均年龄50.9岁），6例具有动脉粥样硬化斑块,12例具有内膜-中膜厚度(IMT)>1mm(动脉粥样硬化疾病的总体患病率:38.2%)。用CDUS检测的所有斑块均在CTA确认。对照组（平均年龄51.3岁），CDUS显示4例患者动脉粥样硬化斑块，4例患者IMT>1mm（总患病率为17％）。各组间动脉粥样硬化性疾病患病率差异有统计学意义(P<0.05)。
结论：我们的研究结果强调，PsO可能被认为是上主动脉血管动脉粥样硬化疾病发展的诱发因素，因为它会导致IMT增加，这也被认为是一个独立的心血管危险因素。
