PDF(Pubmed)
Abstract：
Mitochondrial myopathy encephalopathy lactic acidosis and stroke-like episodes (MELAS) is an important cause of stroke-mimicking diseases that predominantly affect patients before 40 years of age. MELAS results from gene mutations in either mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) responsible for the wide spectrum of clinical symptoms and imaging findings. Neurological manifestations can present with stroke-like episodes (the cardinal features of MELAS), epilepsy, cognitive and mental disorders, or recurrent headaches. Magnetic resonance imaging (MRI) is an important tool for detecting stroke-like lesions, accurate recognition of imaging findings is important in guiding clinical decision making in MELAS patients. With the development of neuroimaging technologies, MRI plays an increasingly important role in course monitoring and efficacy assessment of the disease. In this article, we provide an overview of the neuroimaging features and the application of novel MRI techniques in MELAS syndrome.
摘要：
线粒体肌病脑病乳酸性酸中毒和中风样发作（MELAS）是中风模仿疾病的重要原因，这些疾病主要影响40岁之前的患者。MELAS是由线粒体DNA（mtDNA）或核DNA（nDNA）中的基因突变引起的，该基因突变负责广泛的临床症状和影像学发现。神经系统表现可表现为中风样发作（MELAS的主要特征），癫痫,认知和精神障碍，或者是经常性的头痛.磁共振成像（MRI）是检测中风样病变的重要工具，准确识别影像学表现对指导MELAS患者的临床决策具有重要意义。随着神经影像学技术的发展,MRI在疾病的病程监测和疗效评估中起着越来越重要的作用。在这篇文章中,我们概述了MELAS综合征的神经影像学特征和新型MRI技术的应用.
