Abstract：
Various studies have explored potential therapeutic applications of capsaicin in human medicine, for example in pain, obesity, cancer, cardiovascular and respiratory disease. The aim of this scoping review was to identify and chart available evidence on therapeutic applications of capsaicin in humans using any mode of capsaicin delivery to treat conditions of the respiratory system.
Electronic bibliographic databases (Web of Science, PubMed, Medline, ScienceDirect, Embase, Scopus) were searched from inception to 2021 to identify experimental studies reporting clinical outcomes of therapeutic applications of capsaicin. Studies with or without control group published in peer-reviewed journals were included. Animal studies, studies of human cell lines, and physiological proof of concept studies were excluded. Reviewer pairs independently double-screened 2799 search results for inclusion.
Twenty-three original studies were included. Capsaicin has been investigated for the treatment of non-allergic rhinitis (n = 15), nasal polyposis (n = 3), allergic rhinitis (n = 2), unexplained chronic cough (n = 2), and prevention of aspiration pneumonia (n = 1). Modes of delivery included intranasal application (nasal spray, soaked pads, solution), inhalation, ingestion, and aural ointment. Seventeen studies reported positive effects of capsaicin on clinical outcomes for rhinitis, nasal polyposis, chronic cough, and pneumonia. Sixteen studies reported on the safety of capsaicin, with no reports of significant adverse events and overall fair to good patient acceptability.
While the evidence identified in this review has limited implications for clinical practice, studies support the general safety of capsaicin as administered in these studies and highlight emerging strands of research and clinical hypotheses which warrant further examination.
Electronic bibliographic databases (Web of Science, PubMed, Medline, ScienceDirect, Embase, Scopus) were searched from inception to 2021 to identify experimental studies reporting clinical outcomes of therapeutic applications of capsaicin. Studies with or without control group published in peer-reviewed journals were included. Animal studies, studies of human cell lines, and physiological proof of concept studies were excluded. Reviewer pairs independently double-screened 2799 search results for inclusion.
Twenty-three original studies were included. Capsaicin has been investigated for the treatment of non-allergic rhinitis (n = 15), nasal polyposis (n = 3), allergic rhinitis (n = 2), unexplained chronic cough (n = 2), and prevention of aspiration pneumonia (n = 1). Modes of delivery included intranasal application (nasal spray, soaked pads, solution), inhalation, ingestion, and aural ointment. Seventeen studies reported positive effects of capsaicin on clinical outcomes for rhinitis, nasal polyposis, chronic cough, and pneumonia. Sixteen studies reported on the safety of capsaicin, with no reports of significant adverse events and overall fair to good patient acceptability.
While the evidence identified in this review has limited implications for clinical practice, studies support the general safety of capsaicin as administered in these studies and highlight emerging strands of research and clinical hypotheses which warrant further examination.
摘要：
各种研究已经探索了辣椒素在人类医学中的潜在治疗应用，例如在疼痛中，肥胖，癌症,心血管和呼吸系统疾病。这项范围审查的目的是确定并绘制有关辣椒素在人类中使用任何辣椒素递送方式治疗呼吸系统疾病的治疗应用的可用证据。
电子书目数据库(WebofScience，PubMed,Medline,ScienceDirect,Embase,Scopus）从开始到2021年进行搜索，以确定报告辣椒素治疗应用临床结果的实验研究。包括在同行评审期刊上发表的有或没有对照组的研究。动物研究,人类细胞系的研究，和生理证据的概念研究被排除在外。审阅者独立地对2799个搜索结果进行双重筛选以纳入。
包括23项原始研究。辣椒素已被研究用于治疗非过敏性鼻炎（n=15），鼻息肉病（n=3），过敏性鼻炎（n=2），原因不明的慢性咳嗽（n=2），和预防吸入性肺炎（n=1）。递送方式包括鼻内应用(鼻喷雾剂，浸透的垫子,解决方案)，吸入,摄取，和听觉软膏。17项研究报道了辣椒素对鼻炎临床结局的积极影响，鼻息肉病,慢性咳嗽,和肺炎。16项研究报告了辣椒素的安全性，没有重大不良事件的报告，患者总体可接受性良好。
虽然本综述中确定的证据对临床实践的影响有限，研究支持在这些研究中使用辣椒素的一般安全性,并强调了需要进一步检查的新出现的研究和临床假设.
电子书目数据库(WebofScience，PubMed,Medline,ScienceDirect,Embase,Scopus）从开始到2021年进行搜索，以确定报告辣椒素治疗应用临床结果的实验研究。包括在同行评审期刊上发表的有或没有对照组的研究。动物研究,人类细胞系的研究，和生理证据的概念研究被排除在外。审阅者独立地对2799个搜索结果进行双重筛选以纳入。
包括23项原始研究。辣椒素已被研究用于治疗非过敏性鼻炎（n=15），鼻息肉病（n=3），过敏性鼻炎（n=2），原因不明的慢性咳嗽（n=2），和预防吸入性肺炎（n=1）。递送方式包括鼻内应用(鼻喷雾剂，浸透的垫子,解决方案)，吸入,摄取，和听觉软膏。17项研究报道了辣椒素对鼻炎临床结局的积极影响，鼻息肉病,慢性咳嗽,和肺炎。16项研究报告了辣椒素的安全性，没有重大不良事件的报告，患者总体可接受性良好。
虽然本综述中确定的证据对临床实践的影响有限，研究支持在这些研究中使用辣椒素的一般安全性,并强调了需要进一步检查的新出现的研究和临床假设.
