Abstract：
Late sodium current has long been linked to dysrhythmia and contractile malfunction in the heart. Despite the increasing body of accumulating information on the subject, our understanding of its role in normal or pathologic states is not complete. Even though the role of late sodium current in shaping action potential under physiologic circumstances is debated, it\'s unquestioned role in arrhythmogenesis keeps it in the focus of research. Transgenic mouse models and isoform-specific pharmacological tools have proved useful in understanding the mechanism of late sodium current in health and disease. This review will outline the mechanism and function of cardiac late sodium current with special focus on the recent advances of the area.
摘要：
长期以来，晚期钠电流与心脏的心律失常和收缩功能障碍有关。尽管关于这个问题的信息越来越多，我们对其在正常或病理状态中的作用的理解还不完全。尽管晚期钠电流在生理环境下形成动作电位的作用存在争议，它在心律失常发生中的无可置疑的作用使它成为研究的焦点。转基因小鼠模型和同工型特异性药理学工具已被证明可用于理解晚期钠电流在健康和疾病中的机制。本文将概述心脏晚期钠电流的机制和功能，并特别关注该领域的最新进展。
