Abstract：
The aim of this narrative review was to present research investigating chitosan, including its general characteristics, properties, and medical and dental applications, and finally to present the current state of knowledge regarding the efficacy of chitosan in the treatment of temporomandibular disorders (TMDs) based on the literature. The PICO approach was used for the literature search strategy. The PubMed database was analyzed with the following keywords: (\"chitosan\"[MeSH Terms] OR \"chitosan\"[All Fields] OR \"chitosans\"[All Fields] OR \"chitosan s\"[All Fields] OR \"chitosane\"[All Fields]) AND (\"temporomandibular joint\"[MeSH Terms] OR (\"tem-poromandibular\"[All Fields] AND \"joint\"[All Fields]) OR \"temporomandibular joint\"[All Fields] OR (\"temporomandibular\"[All Fields] AND \"joints\"[All Fields]) OR \"temporo-mandibular joints\"[All Fields]). After screening 8 results, 5 studies were included in this review. Chitosan presents many biological properties and therefore it can be widely used in several branches of medicine and dentistry. Chitosan promotes wound healing, helps to control bleeding, and is used in wound dressings, such as sutures and artificial skin. Apart from its antibacterial property, chitosan has many other properties, such as antifungal, mucoadhesive, anti-inflammatory, analgesic, antioxidant, antihyperglycemic, and antitumoral properties. Further clinical studies assessing the efficacy of chitosan in the treatment of TMD are required. According to only one clinical study, chitosan was effective in the treatment of TMD; however, better clinical results were obtained with platelet-rich plasma.
摘要：
这篇叙述性综述的目的是介绍研究壳聚糖，包括它的一般特征，属性,以及医疗和牙科应用，最后介绍了基于文献的关于壳聚糖在治疗颞下颌关节紊乱病（TMD）中的功效的知识现状。文献检索策略采用PICO方法。PubMed数据库使用以下关键字进行了分析：（\"壳聚糖\"[MeSH术语]或\"壳聚糖\"[所有字段]或\"壳聚糖\"[所有字段]或\"壳聚糖\"[所有字段]或\"壳聚糖\"[所有字段]或\""壳聚糖\"[所有字段])和(\"""颞关节\MeSH术语\\\下颌关节\"所有筛选8项结果后，本综述包括5项研究。壳聚糖具有许多生物学特性，因此可广泛用于医学和牙科的多个分支。壳聚糖促进伤口愈合，有助于控制出血,用于伤口敷料，如缝线和人造皮肤。除了它的抗菌性能，壳聚糖具有许多其他性质，如抗真菌药，粘膜粘着剂,抗炎,镇痛药,抗氧化剂，抗高血糖,和抗肿瘤特性。需要进一步的临床研究来评估壳聚糖在治疗TMD中的功效。只有一项临床研究表明,壳聚糖在治疗TMD中是有效的；然而，使用富血小板血浆获得了更好的临床结果。
