Abstract：
The objective of this study is to investigate whether kisspeptin levels in early pregnancy have a better diagnostic value on early pregnancy outcome as compared with human chorionic gonadotropin (hCG). This study was a systematic review and meta-analysis aiming to investigate the diagnostic value of kisspeptin levels on early pregnancy outcome. The primary outcome was miscarriage or viable intrauterine pregnancy. Five studies were included for systematic review, and three studies were included for meta-analysis. Meta-analysis showed kisspeptin levels had a good diagnostic value with the area under the curve (AUC) 0.902 (0.866, 0.937) when kisspeptin was measured after 6 weeks of gestation. Sensitivity analysis demonstrated kisspeptin levels had a diagnostic value with AUC = 0.881 (0.855, 0.906). hCG levels had a diagnostic value with AUC = 0.834 (0.785, 0.883), which was inferior to the diagnostic value of kisspeptin (mean difference = 0.09 (0.02, 0.16)). Kisspeptin measurement has a potential for comparable or even higher accuracy than hCG in differentiating between miscarriage and viable intrauterine pregnancy after 6 weeks of gestation.
摘要：
这项研究的目的是调查与人绒毛膜促性腺激素（hCG）相比，妊娠早期的kisspeptin水平是否对早期妊娠结局具有更好的诊断价值。本研究是一项系统评价和荟萃分析，旨在探讨kisspeptin水平对早期妊娠结局的诊断价值。主要结局是流产或宫内妊娠。纳入了五项研究进行系统评价，纳入三项研究进行荟萃分析。Meta分析显示，妊娠6周后测量kisspeptin的曲线下面积（AUC）为0.902（0.866，0.937），kisspeptin水平具有良好的诊断价值。敏感性分析表明kisspeptin水平具有诊断价值，AUC=0.881（0.855，0.906）。hCG水平具有AUC=0.834（0.785，0.883）的诊断价值，劣于kisspeptin的诊断价值（平均差=0.09（0.02，0.16））。在妊娠6周后，Kisspeptin测量在区分流产和可行的宫内妊娠方面具有与hCG相当甚至更高的准确性。
