Abstract：
Background and Objectives: High rates of infection with Toxoplasma gondii were found in psychiatric patients globally. In this study, we assessed for the first time the prevalence of T. gondii infection in psychiatric patients and healthy individuals with no known psychiatric disorders in Western Romania. Materials and Methods: The presence of specific IgG anti-T. gondii antibodies was evaluated in 308 psychiatric patients and 296 control subjects using a chemiluminescence assay. Results: Overall, the seroprevalence of IgG antibodies was higher in psychiatric patients (67.86%; 209/308), compared with the control group (54.05%; 160/296) (p < 0.001). Our results revealed a significantly higher prevalence of T. gondii antibodies among patients with schizophrenia (69.77%), organic (personality and behaviour) disorders (76.74%), and mental disorders concerning alcohol abuse (84.62%), compared with the control group (p = 0.009, p = 0.005, p = 0.043, respectively). Conclusions: This study provides new and important information on the seroprevalence of T. gondii in Romanian psychiatric patients and may serve for further scientific research regarding the status of T. gondii infection in patients with psychiatric disorders.
摘要：
背景与目的：全球精神病患者弓形虫感染率高。在这项研究中,我们首次评估了罗马尼亚西部精神病患者和无已知精神疾病的健康个体中弓形虫感染的患病率.材料和方法：特异性IgG抗T。使用化学发光法评估了308名精神病患者和296名对照受试者的刚地抗体。结果：总体而言，精神病患者IgG抗体的血清阳性率较高（67.86%;209/308），与对照组相比（54.05％；160/296）（p<0.001）。我们的结果显示，精神分裂症患者中弓形虫抗体的患病率明显更高(69.77%)。器质性（人格和行为）障碍（76.74％），与酗酒有关的精神障碍(84.62%)，与对照组相比（分别为p=0.009，p=0.005，p=0.043）。结论：本研究提供了有关罗马尼亚精神病患者弓形虫血清阳性率的新的重要信息，并可能为有关精神疾病患者弓形虫感染状况的进一步科学研究提供依据。
